摘要
目的探讨子痫前期孕妇的血脂、血糖与维生素A、E的水平及其临床意义。方法纳入孕产妇5 000例,根据子痫前期发病情况分为子痫前期组500例与对照组4 500例,比较两组的血清维生素A、E水平和血糖、血脂水平,分析子痫前期孕妇维生素A、E水平与血脂、血糖水平的相关性。结果子痫前期组的血清维生素A、E及HDL水平均低于对照组,而TC、TG、LDL、FBG水平均高于对照组(均P<0.05)。子痫前期孕妇的血清维生素A、E水平与LDL、FBG、TG水平呈负相关(P<0.05),与HDL水平呈正相关(P<0.05)。多重线性回归分析显示子痫前期组的维生素A、E水平均与LDL、FBG水平呈负相关(P<0.05)。结论子痫前期孕产妇孕期维生素A、E水平低,且血脂与血糖水平紊乱,两者可能共同参与了子痫前期的发生发展。
Objective To investigate the expression levels and clinical significance of blood lipids, blood glucose,vitamin A and E in pregnant women with preeclampsia. Methods A total of 5 000 pregnant women were enrolled and were divided into preeclampsia group （n = 500） and control group （n = 4 500） according to the incidence of preeclampsia. The levels of serum vitamin A and E, blood glucose and blood lipids were compared between the two groups. The correlation of vitamin A and E levels with blood glucose and blood lipids levels was analyzed in the pregnant women with preeclampsia. Results The serum vitamin A and E, HDL levels were lower while the TC, TG, LDL and FBG levels were higher in the preeclampsia group compared to the control group（ all P 〈 0.05 ）. In the pregnant women with preeclampsia, the serum levels of vitamin A and E negatively correlated with the levels of LDL, FBG and TG （ P 〈 0.05 ） , and positively correlated with the levels of HDL （ P 〈 0.05 ）. Multiple linear regression analysis showed that the levels of vitamin A and E in the pre-eclampsia group negatively correlated with the levels of LDL and FBG （ P 〈 0.05 ）. Conclusion Reduced vitamin A and E levels, dyslipidemia and dysglyeemia are observed in the pregnant women with preeclampsia, and are probably involved in the incidence and progression of preeclampsia.
作者
郭冰杰
杨彩梅
GUO Bing-jie YANG Cai-mei(Department of Gynaecology and Obstetrics, Shunyi Hospital Branch,Beijing Hospital of Traditional Chinese Medicine, Beijing 101300, China)
出处
《广西医学》
CAS
2017年第10期1474-1476,1479,共4页
Guangxi Medical Journal
基金
国家卫生计生委医药卫生科技发展研究中心基金(W2016CWBJ04)
关键词
子痫前期
维生素A
维生素E
血脂
血糖
Preeclampsia, Vitamin A, Vitamin E, Blood lipids, Blood glucose
