摘要
目的:评价中医药联合5型磷酸二酯酶抑制剂(PDE5抑制剂)治疗阴茎勃起功能障碍(ED)的临床疗效。方法:计算机检索中国知识资源总库、中国生物医学文献数据库、万方数据库,收集中医药联合PDE5抑制剂治疗ED的随机对照临床试验或半随机对照临床试验,检索时限从1998-2016年,对纳入研究的方法学质量进行评价,用RevMan5.3软件进行统计分析。结果:最终纳入22篇研究文献,共1825例患者。Meta分析显示:与对照组相比,中医药联合PDE5抑制剂治疗ED在治愈率[OR=1.88,95%CI(1.44,2.44),P<0.05]、总有效率[OR=2.65,95%CI(2.01,3.48),P<0.05]、国际勃起功能问卷5(IIEF-5)[MD=3.51,95%CI(2.63,4.38),P<0.05]及中医症状积分[MD=-6.66,95%CI(-9.36,-3.96),P<0.05]差异均有统计学意义,但两组不良反应[OR=0.79,95%CI(0.48,1.31),P>0.05]差异没有统计学意义。发表性偏倚分析提示纳入研究文献可能存在潜在的发表偏倚。结论:中医药联合PDE5抑制剂治疗ED,应用安全,在治愈率、总有效率、IIEF-5评分及中医症状积分方面优于对照组,副作用与对照组相当,但仍需更多临床研究进一步证实及验证。
Objective：To evaluate the clinical efficacy of Chinese medicine combined with PDE5i in the treatment of Erectile Dys function（ED）. Methods： Retrieved from China Knowledge Resources, Chinese Biomdical literature Database and Wanfang Data- base, randomized or quasi-randomized controlled trials about Chinese medicine combined with PDE5i therapy for ED were collected, the evaluated by the methodological quality,statistical analyzed with RevMen 5.3 software. Results：22 studies involving 1825 pa tients entered the inclusion criteria. Compared with the control group, the results of meta analysis showed that Chinese medicine corn bined with PDE5i therapy for ED in the cure rate[OR= 1.88,95%CI（1.44,2.44）,P〈0. 051, the total effective rate,OR=2. 65, 95%CI（2.01,3.48） ,P〈0. 05] ,IIEF5 score[MD= 3.51,95%CI（2.63,4.38）, P〈0. 05] ,and traditional Chinese medicine symptom integral[MD=-6.66,95%CI（- 9.36,-3.96）, P〈0. 05] ,the difference was statistically significant, However, the side effect[OR = 0.79,95 %CI（0. 48,1. 31 ）, P〉0. 05], the difference was not significant. ＂Funnel Plot＇ bias analysis indicate that there may be a po tential publication bias. Cone｜usion：Chinese medicine combined with PDESi therapy for ED in the cure rate, the total effective rate ,IIEF5 score and traditional Chinese medicine symptom integral is superior to the control group, the side effect is equivalent to the control group, But still need more clinical research to further confirm and verify.
出处
《亚太传统医药》
2017年第20期76-81,共6页
Asia-Pacific Traditional Medicine
