摘要
谷氨酸是哺乳动物中枢神经系统中最主要的兴奋性神经递质,位于突触间隙中的谷氨酸有赖于位于胶质细胞和神经元细胞膜上的高亲和力谷氨酸转运体给予及时清除,维持其正常的生理功能。谷氨酸转运体的量或功能异常,会引起多种生理功能紊乱。研究表明高亲和力谷氨酸转运体在慢性疼痛产生过程中发挥重要作用,可能成为疼痛治疗的新靶点。
Glutamate serves as a major excitatory neurotransmitter in the mammalian central nervous system and is stored in synaptic cleft by an uptake system that is dependent on the high-affinity glutamate transporters （ETTAs）, which locate in the plasma membrane of glial cells and neurons. ETTAs can rapidly terminate the action of glutamate and maintain its normal physiological functions. If the content or function of glutamate transporters is abnormal, it can result in many physiological dysfunctions. Studies have demonstrated that high-affinity glutamate transporters play an important role in the development of chronic pain, which might be a new therapeutic target for the pain.
作者
张华
王胜红
解琪琪
李文洲
史卫东
马靖琳
汪静
ZHANG Hua WANG Shenghong XIE Qiqi LI Wenzhou SHI Weidong MAjinglin WANG Jing(Department of Orthopedics, Lanzhou University Second Hospital Key Laboratory of Orthopedics Disease of Gansu Province, Lanzhou 730000, China)
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2017年第9期1094-1099,共6页
Journal of Central South University ：Medical Science
基金
国家自然科学基金(81371230)
甘肃省科技厅-青年科技基金(1506RJYA200)~~
