摘要
肺癌的发病率在全世界所有癌症中已占据首位,随着其发病率与死亡率的逐年增高,预防与控制肺癌成为世界普遍关注的问题。茶是一种保健饮品,味甘、苦,微寒,无毒,大量实验研究表明,茶叶中富含的多种功能性成分可用于预防、直接干预或辅助治疗肺癌等恶性肿瘤,可作为天然抗癌药物。茶中的茶多酚、咖啡碱、茶色素、茶氨酸、茶多糖等均可有效地抑制肿瘤细胞的分裂增殖、诱导肿瘤细胞凋亡、调控肿瘤发生相关的基因和蛋白表达。对1970年以来,茶中含有的一些主要的功能性成分预防和治疗肺癌的研究进展进行综述,以期为阐明茶干预抵抗肺癌的作用机制、更安全有效地利用茶及茶功能性成分抵抗肺癌、培育特定成分量高的茶树新品种、开发新型茶产品提供参考。
Lung cancer has the highest incidence among all of the world＇s cancer diseases. Since the incidence and mortality of lung cancer have been increasing year after year, how to prevent and control it arouses general concern in the world. Tea is a healthy drink and has sweet-bitter flavor. It is also slightly cold and non-toxic. Many experimental studies show that a variety of functional components included in tea can be used for preventing, directly intervening and assistantly treating lung cancer or other malignant tumors, so they will be a potential candidate for natural antitumor drugs. For example, tea polyphenols, caffeine, tea pigment, theanine and tea polysaccharide can well inhibit the proliferation of tumor cells, induce apoptosis of tumor cells as well as regulate the expression of related gene and protein. The paper reviews some major researches of prevention and treatment on lung cancer by functional components of tea since 1970, in order to provide reference of systematically cognizing tea＇s mechanism on opposing lung cancer, using tea and functional components to resist lung cancer in a safe and effective way, cultivating new varieties of tea armed with high level of specific components and developing new tea products.
出处
《中草药》
CAS
CSCD
北大核心
2017年第17期3654-3661,共8页
Chinese Traditional and Herbal Drugs
基金
福建农林大学2016年度科技创新专项基金项目(CXZX2016102)
福建省人力资源和社会保障厅项目([2012]398号)
关键词
茶多酚
咖啡碱
茶色素
茶氨酸
茶多糖
肺癌
tea polyphenols
caffeine
tea pigment
theanine
tea polysaccharide
lung cancer
