摘要
目的探讨不规则抗体的分布特点及临床意义。方法对该院2014-01~2016-07检测出的111例不规则抗体筛查阳性的患者,采用盐水法、抗球蛋白法进行抗体特异性鉴定。结果 111例不规则抗体阳性中自身抗体15例,自身抗体+同种抗体3例,抗筛阳性未确定抗体特异性24例,其余69例标本中检出同种特异性抗体76例,其中联合抗体7例。76例同种特异性抗体中Rh、MNS、Lewis血型系统不规则抗体比例较高,分别占52.63%、28.95%和10.53%,其中抗-E(34.21%)、抗-Mur(17.11%)、抗-M(10.53%)、抗-Lea(10.53%)检出率最高。血液免疫系统疾病患者和妊娠者抗筛阳性比例较高,分别占总抗筛阳性患者的27.03%和20.72%。结论输血前不规则抗体检测(特别对有输血史或妊娠史的患者)非常必要,对提高输血治疗效果,减少输血不良反应,保证临床输血安全具有重要意义。
Objective To investigate the distribution characteristics and clinical significances of irregular antibodies. Methods 111 patients with positive irregular antibodies in screening from January 2014 to July 2016 were tested for antibody specificity by the saline method and the antiglobulin method. Results Among the 111 cases tested for positive irregular antibodies, autoantibodies can be detected in 15 cases, and autoantibodies and isotype an- tibodies in 3 cases. Antibody specificity was not detected out in 24 cases of 76 cases, alloantibodies were detected in 69 cases, including 7 cases of combined antibodies. The positive rate was high in Rh system, MNS system and Lewis system, which accounted for 52. 63%, 28. 95% and 10. 53% respectively. The top four antibodies were anti-E （34. 21% ）, anti-Mur（ 17.11% ）, Anti-M（ 10. 53% ） and anti-Lea（ 10. 53% ）. The positive rate was high in the pa- tients who had hematologic disease and pregnancy, which accounted for 27.03% and 20. 72% respectively. Conclu- sion It is necessary to detect irregular antibodies before blood transfusion, especially for the patients who have a his- tory of blood transfusion or pregnancy.
出处
《中国临床新医学》
2017年第8期754-757,共4页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
关键词
不规则抗体
抗体筛查
患者
Irregular antibodies
Irregular antibody screening
Patients
