摘要
【目的】探讨信号转导与转录激活因子4(STAT4)基因rs10181656及rs16833431位点多态性与子痫前期相关性的关系。【方法】应用聚合酶链反应-限制性片段长度多态性法检测228名子痫前期患者(病例组)和179名健康孕妇(对照组)的STAT4基因rs10181656 C/G及rs16833431 C/T位点的基因型频率。【结果】(1)rs10181656位点在病例组中C/C、C/G及G/G基因型频率分别是35.96%、47.81%及16.23%,而对照组中的三种基因型的频率分别是46.37%、44.69%及8.94%,C/C、C/G及G/G基因型频率在病例组和对照组中分布具有统计学差异(P=0.031),C、G等位基因频率在病例组和对照组中分布具有统计学差异(P=0.009);(2)rs16833431位点:三种基因型和C、T等位基因频率在病例组和对照组的分布无统计学意义(P=0.508,0.461)。【结论】STAT4基因rs10181656位点多态性与子痫前期相关,而rs16833431位点多态性与子痫前期发病无关。
【Objective】To investigate associations between the functional polymorphisms of signal transducer and activator of transcription 4（STAT4）gene and preeclampsia.【Methods】PCR-restriction fragment length polymorphism was used to genotype rs10181656 and rs16833431 local polymorphism in 228 preeclampsia cases and 179 normal controls.【Results】（1）The frequencies of rs10181656C/G were 35.96%,46.37% in genotype C/C,47.81%,44.69% in genotype C/G and 16.23%,8.94% in genotype G/G between preeclampsia patients and normal controls. They reached statistical difference（P = 0.031）. There was different distribution in two alleles（C and G）between preeclampsia patients and normal controls（P = 0.009）.（2）There was no different distribution in 3genotypes（C/C,C/T,T/T）and 2 alleles（C and T）of rs16833431 C/T between preeclampsia patients and normal controls（P =0.508,0.461）.【Conclusions】Functional polymorphisms of the rs10181656 locus could associate with the preeclampsia. The polymorphisms of the rs16833431 locus could not associate with the preeclampsia.
作者
李银广
李珠玉
李婕
侯文汇
李小青
林敏欢
游泽山
LI Yin-guang LI Zhu-yu LI Jie HOU Wen-hui LI Xiao-qing LIN Min-huan YOU Ze-shan(Department of Obstetrics and Gynecology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China)
出处
《中山大学学报（医学科学版）》
CAS
CSCD
北大核心
2017年第5期705-709,共5页
Journal of Sun Yat-Sen University:Medical Sciences
基金
广东省自然科学基金(S2011010003522)
