摘要
目的探讨孕晚期膳食摄入情况与子痫前期发生的关系。方法采用1∶1匹配的病例-对照研究,选择2016年3—12月在郑州大学第一附属医院产科住院分娩的子痫前期患者131例为病例组,按照年龄±3岁、孕周±2周,随机选取血压正常且没有蛋白尿的孕妇131例为对照组。通过食物频率问卷(FFQ)及自制孕期健康危险因素调查问卷,调查研究对象近3个月的膳食摄入情况,并计算平均每天各种营养素的摄入量,采用条件Logistic回归对统计结果进行分析。结果多因素条件Logistic回归发现,病例组的孕前体质指数(OR=1.18,95%CI 1.08～2.82)和孕期增重(OR=1.51,95%CI 1.15～1.97)均高于对照组,该组孕妇红黄色水果(OR=0.76,95%CI 0.60～0.98)的摄入量、以及膳食中维生素C(OR=0.57,95%CI 0.33～0.99)和叶酸(OR=0.36,95%CI 0.18～0.72)摄入量均低于对照组,两组之间的差异有统计学意义(P<0.05)。结论过高的孕前体质指数和孕期增重过多是子痫前期的危险因素,妊娠期适当增加红黄色水果的摄入有利于预防子痫前期的发生,维生素C和叶酸的摄入可能是子痫前期的保护因素。
OBJECTIVE To investigate the relationship between dietary intake during the third trimester and preeclampsia.METHODS A case-control study with 1:1 matching was performed.A total of 131 patients with preeclampsia hospitalized in the First Affiliated Hospital of Zhengzhou University from March 2016 to December 2016 were selected as the case group.According to age±3 years and gestational age±2 weeks,131 pregnant women with normal blood pressure and no proteinuria in the hospital were randomly selected as the control group.The questionnaires of food frequency and gestational health risk factors in the past three months were conducted and the average daily intakes of various nutrients were calculated.Conditional Logistic regression was applied to analyze the data.RESULTS Multivariate conditional Logistic regression showed that pre-pregnancy body mass index(OR=1.18,95%CI 1.08-2.82)and gestational weight gain(OR=1.51,95%CI 1.15-1.97)were higher,while the intakes of red and/or yellow fruits(OR=0.76,95%CI 0.60-0.98),and dietary vitamin C(OR=0.57,95%CI 0.33-0.99)and folic acid(OR=0.36,95%CI 0.18-0.72)were lower in case group than that in control group(P<0.05).CONCLUSION Higher pre-pregnancy body mass index and over gestational weight gain are the risk factors for pre-eclampsia.Appropriate increase of red and/or yellow fruit intake during pregnancy may be beneficial to prevent pre-eclampsia.Vitamin C and folic acid intake might be protective factors for pre-eclampsia.
作者
窦伟峰
赵先兰
吕全军
段丹丹
陈改云
付文君
刘艳华
王玲
Dou Weifeng;Zhao Xianlan;Lii Quanjun;Duan Dandan;Chen Gaiyun;Fu Wenjun;Liu Yanhua;Wang Ling(College of Public Health,Zhengzhou University,Zhengzhou 450001,China;The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450001,China;New Area People' s Hospital of Luoyang,Luoyang 471023,China)
出处
《卫生研究》
CAS
CSCD
北大核心
2019年第2期232-237,共6页
Journal of Hygiene Research
基金
国家自然科学基金(No.81602852)
