摘要
目的观察和评价国产抗结核药物固定剂量复合制剂治疗老年初治菌阳肺结核的疗效及安全性。方法收集老年初治菌阳肺结核患者94例,以使用固定剂量复合剂的46例为治疗组,以使用散药异烟肼(H)、利福平(R)、吡嗪酰胺(Z)、乙胺丁醇(E)的48例为对照组。观察两组近期痰菌阴转、胸部X线病灶改变、不良反应等情况。结果第2个月末,治疗组和对照组痰涂片阴转率和培养阴转率分别为76.1%和71.7%、75.0%和72.9%,治疗满6个月时,治疗组和对照组痰涂片阴转率和培养阴转率分别为89.1%和91.3%、89.6%和89.6%。胸部X线明显改善(显吸及吸收),治疗组与对照组病灶吸收率分别为89.1%及89.6%。治疗组和对照组分别有4例(8.7%)、5例(10.4%)肝功能异常。结论固定剂量复合制剂与散药的治疗效果相同,不良反应相近,在老年肺结核患者治疗中值得推广应用。
Objective To evaluate the clinical efficacy of domestic fixed-dose compound in the treatment of elderly patients with new smear positive pulmonary tuberculosis（TB）. Methods The medical records were reviewed analyzed for new smear positive pulmonary TB elderly patients, and they were divided into a treatment group who received the domestic fixeddose compound（46 cases） and a control group who were given single formulation of isoniazid（H） rifampicin（R） pyrazinamide（Z） ethambutol（E）（48 cases）. The sputum negative conversion rates, X-ray focus changes and side-effects were observed and compared between two groups. Results The sputum smear and culture negative conversion rates at the 2nd month in the treatment group were 76.1% and 71.7%, and those in the control group were 75.0% and 72.9% respectively. The sputum smear and culture negative conversion rates at the 6th month in the treatment group were 89.1% and 91.3% and those in the control were 89.6% and 89.6% respectively. The chest radiography showed remarkable improvement in both groups, and the resolution rates of pulmonary lesions in the treatment group and control group were 89.1% and 89.6% respectively. Four patients（8.7%）defaulted because of hepatic dysfunction in the treatment group and five patients（10.4%） in the control group. Conclusions The treatment outcome and adverse effects of the domestic fixed-dose compound are similar to those of the single formulation of drugs in the treatment of elderly patients with new smear positive pulmonary tuberculosis; therefore the domestic fixed-dose compound could be recommended for wider use in TB control.
作者
朱岩
闫美凤
张立英
ZHU Yan YAN Meifeng ZHANG Liying(Beijing Chaoyang Center for Diseases Prevention and Control, Beijing 100089, China)
出处
《中国热带医学》
CAS
2017年第9期936-938,共3页
China Tropical Medicine
关键词
固定剂量复合剂
肺结核
老年
药物疗法
fix-dose compound
pulmonary tuberculosis
elderly
drug therapy
