摘要
目的研究分析在初治菌阳肺结核患者中采取莫西沙星超短程治疗方案开展治疗的临床效果。方法选取在本院2016年6月至2018年3月接受治疗的初治菌阳肺结核患者102例作为研究对象。通过随机数字表格法分组,分成对照组和观察组,各51例。对照组中患者接受2HRZE/4HR化学疗法进行治疗,观察组中患者选用2HRZEM或者2HRM疗法进行治疗,同时加用莫西沙星。分析两组患者治疗效果。结果观察组患者治疗2个月时以及疗程结束时的痰结核菌转阴率均显著高于对照组(P<0.05),观察组中患者病灶吸收有效率为98.04%,对照组中病灶吸收有效率为86.27%,组间差异具有统计学意义(P<0.05),观察组中患者不良反应率为5.88%,对照组中患者的不良反应率为7.84%,组间差异无统计学意义。结论临床上针对初治菌阳肺结核患者实施莫西沙星超短程治疗效果良好,有利于提升痰结核菌转阴率,加快病灶吸收,且不良反应少,安全性高,值得推广。
Objective To study and analyze the clinical effect of moxifloxacin ultra-short-course treatment in patients with newly diagnosed pulmonary tuberculosis.Methods The patients with newly diagnosed pulmonary tuberculosis who were treated in our hospital were selected as the research subjects.The time period was from June 2016 to March 2018,and the number of cases was 102 cases.They were grouped by random number table method and and divided into control group and observation group,51 cases each.Patients in the control group received 2HRZE/4HR chemotherapy.Patients in the observation group were treated with 2HRZEM or 2HRM therapy,and moxifloxacin was added.The therapeutic effects of the two groups of patients were analyzed.Results The rate of sputum tuberculosis in the observation group was significantly higher than that in the control group at 2 months and at the end of the treatment period(P<0.05).The effective rate of lesion absorption in the observation group was 98.04%.The efficiency was 86.27%,the difference between the groups was statistically significant(P<0.05).The adverse reaction rate was 5.88%in the observation group and 7.84%in the control group.The difference between the groups was not statistically significant.Conclusion The clinical application of moxifloxacin in patients with newly diagnosed pulmonary tuberculosis is effective,which is beneficial to improve the negative rate of tuberculosis,accelerate the absorption of lesions,and has fewer adverse reactions and high safety.It is worth promoting.
作者
兰冀雪
Lan Jixue(Department of Functional Section,Benxi City Sixth Hospital,Benxi,Liaoning,117000,China)
出处
《当代医学》
2019年第27期45-47,共3页
Contemporary Medicine
关键词
初治菌阳肺结核
疗效
超短程
莫西沙星
痰结核菌转阴率
不良反应
Initial treatment of pulmonary tuberculosis
Efficacy
Ultra short-range
Moxifloxacin
Sputum tuberculosis conversion rate
Adverse reactions
