摘要
目的:探讨胰岛素自身抗体(IAA)、胰岛细胞抗体(ICA)及谷氨酸脱羧酶抗体(GADA)联合检测对糖尿病分型的诊断价值。方法:选择2015年6月~2016年6月在我院进行诊治的1型糖尿病患者30例为A组,2型糖尿病患者60例为B组,同期在我院进行体检健康者50例为C组,采用酶联免疫吸附法(ELISA)检测三组的IAA、ICA及GADA,比较三组的阳性检出率。结果:A组空腹血糖为(10.12±3.68)mmol/L,B组空腹血糖为(11.23±3.26)mmol/L,A组和B组的空腹血糖均明显高于C组(4.35±1.42mmol/L)(P<0.05),但A组和B组的空腹血糖相比无明显差异(P>0.05);A组和B组的IAA、ICA及GADA单独和联合检测的阳性率均明显高于C组(P<0.05),且A组的IAA、ICA及GADA单独和联合检测的阳性率明显高于B组(P<0.05);IAA、ICA及GADA联合检测对1型和2型糖尿病的敏感性和特异性均明显高于单独检测(P<0.05)。结论:IAA、ICA及GADA联合检测对糖尿病分型具有较高的临床诊断价值。
Objective：To study the diagnostic value of combined detection of IAA,ICA and GADA in the classification of diabetes mellitus.Methods：30 cases of patients with type 1 diabetes who were treated in our hospital from June 2015 to June 2016 were selected as A group,60 cases of patients with type 2 diabetes were selected as B group,50 cases of healthy people were selected as C group.The IAA,ICA and GADA of the three groups were detected by ELISA,and the positive rate of the three groups were compared.Results：The fasting glucose of A group was（10.12±3.68） mmol/L,B group was（11.23±3.26） mmol/L,A group and B group were significantly higher than that of C group（P〈0.05）,but there was no significant difference between A group and B group（P〉0.05）;the positive rates of GADA,ICA and IAA in A group and B group were significantly higher than those in C group（P〈0.05）,and the positive rates of GADA,ICA and IAA in A group were significantly higher than those in B group（P〈0.05）;the sensitivity and specificity of combined detection of IAA,ICA and GADA in type 2 and type 1 diabetes mellitus were significantly higher than that in the single test（P〈0.05）.Conclusions：The combined detection of IAA,ICA and GADA has a high diagnostic value in the classification of diabetes mellitus,which is worth clinical application.
出处
《现代生物医学进展》
CAS
2017年第24期4759-4761,共3页
Progress in Modern Biomedicine
