摘要
正常人体中高尔基体蛋白73(GP73)的表达水平很低,而在肝病及肝细胞癌患者中显著表达,因此其或可成为一种新型的肝细胞癌标志物。介绍了GP73在人体内的分布,初步划分了GP73的亚型,并依据不同亚型探讨了其与肝脏良恶性病变和相关外科手术的关系,以及GP73在良恶性病变鉴别中的应用现状。鉴于GP73与肝病的发生、发展和预后关系密切,故对最新的相关基础研究进展进行了归纳,阐述了岩藻糖基化GP73与肝癌细胞增殖、迁移和侵袭的结构基础及已发现的信号通路,并列举了其他可能影响GP73表达水平的因素。
Golgi protein 73（ GP73） has a very low expression level in normal people,while it has a significantly higher expression level in patients with liver diseases and hepatocellular carcinoma（ HCC）,and therefore,it may become a new marker for HCC. This article introduces the distribution of GP73 in human body and definitions of different subtypes of GP73 and elaborates on its association with benign/malignant liver diseases and surgical operation based on the subtypes of GP73,as well as the application of GP73 in the differentiation of benign/malignant liver diseases. Since GP73 is closely associated with the development,progression,and prognosis of liver diseases,this article summarizes the latest advances in basic research,introduces the structural basis of fucosylated GP73 and proliferation,migration,and invasion of hepatoma cells and known signaling pathways,and lists the factors which affect the expression of GP73.
出处
《临床肝胆病杂志》
CAS
2017年第8期1595-1598,共4页
Journal of Clinical Hepatology
基金
甘肃省消化系肿瘤重点实验室开放课题(lzujbky-2011-t03-04)
