摘要
目的探讨慢性丙型肝炎(CHC)患者血清高尔基体蛋白73(GP73)水平与肝功能及丙型肝炎病毒(HCV)-RNA载量的相关性。方法选取该院2012年8月至2018年9月收治的CHC患者84例,按照HCV-RNA水平分为HCV-RNA阴性组(n=23)和HCV-RNA阳性组(n=61),另纳入同期84例健康体检者为对照组,与病例组1∶1匹配,比较3组对象血清GP73及肝功能相关指标水平;同时将61例CHC HCV-RNA阳性患者依据血清GP73水平分为高GP73组、中GP73组、低GP73组3个亚组,比较3组患者HCV-RNA及肝功能指标水平。结果HCV-RNA阳性组和HCV-RNA阴性组患者血清GP73及肝功能相关指标水平均高于对照组(P<0.001),且HCV-RNA阳性组血清GP73及肝功能相关指标水平高于HCV-RNA阴性组(P<0.001);HCV-RNA阳性高GP73组不同肝功能指标及HCV-RNA水平均高于中、低GP73组(P<0.001),且中GP73组不同肝功能指标及HCV-RNA水平均高于低GP73组(P<0.001);HCV-RNA阳性患者血清GP73水平与丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBIL)及HCV-RNA水平均呈正相关(r=0.621、0.652、0.604、0.618,P<0.05)。结论血清GP73水平可为CHC患者的确定和改善预后提供重要的价值。
Objective To investigate the correlation between serum Golgi protein 73(GP73)level with the liver func tion and hepatitis C virus RNA(HCV-RNA)load in the patients with chronic hepatitis C(CHC).Methods Eighty-four patients with CHC admitted to this hospital from August 2012 to August 2018 were selected and divided into the HCV-RNA negative group(23 cases)and HCV-RNA positive group(61 cases)according to the HCV-RNA level.Contemporaneous 84 persons undergoing the healthy physical examination were included as the control group and matched with the case group at 1∶1.The serum GP7 level and liver function related indexes levels were compared among the three groups.At the same time,the 61 CHC cases of HCV-RNA positive were divided into 3 subgroups:the high GP73 group,middle GP73 group and low GP73 group according to serum GP73 level.The levels of HCV-RNA and liver function indicators were compared among 3 groupsResults The levels of serum GP73 and liver function indexes in the HCV-RNA positive group and HCV-RNA negative group were higher than those in the control group(P<0.001),moreover the levels of serum GP73 and liver function indexes in the HCV-RNA positive group were higher than those in the HCV-RNA negative group(P<0.001).The levels of different hepatic function indexes and HCV-RNA in the HCV-RNA positive high GP73 group were higher than those in the middle GP73 group and low GP73 group(P<0.001),moreover the levels of different liver function indexes and HCV-RNA in the middle GP73 group were higher than those in the low GP73 group(P<0.001).There was a positive correlation between serum GP73 level with the levels of ALT,AST,TBIL and HCV-RNA in the patients with HCV-RNA positive(r=0.621,0.652,0.604,P<0.05).Conclusion The serum GP73 level in the patients with CHC may provide the important value for the determination and prognosis improvement in the patients with CHC.
作者
林桂花
杨晓冬
钟文
叶仁清
LIN Guihua;YANG Xiaodong;ZHONG Wen;YE Renqing(Department of Blood Transfusion,Affiliated Ningde Hospital,Fujian Medical University,Ningde,Fujian 352100,China;Department of Clinical Laboratory,Affiliated Ningde Hospital,Fujian Medical University,Ningde,Fujian 352100,China)
出处
《重庆医学》
CAS
2021年第10期1693-1696,共4页
Chongqing medicine
基金
福建省宁德市卫生和计划生育委员会医技提示科研项目[宁财社《指》(2016)41号,2109901]。
