摘要
目的:观察研究黄芪注射液联合巴氯芬对脑瘫患儿的临床疗效。方法:选取我科室2013年6月至2015年5月收治疗的确诊为脑瘫患儿的患者共60例,按随机数字表法分为观察组和对照组各30例,对照组给予常规巴氯芬西药治疗,观察组在对照组的基础上给予黄芪注射液治疗,30天为一个疗程,两组均治疗6个疗程。随访并记录两组患者相关指标变化情况。结果:观察组患者治疗后发育商值和智商值分别为(60.58±5.38、65.57±6.46)分,优于对照组(51.36±5.21、55.58±6.05)分。观察组治疗后日常生活能力(ADL)值为67.58±6.30分,明显优于对照组55.94±6.14分。观察组治疗后血清IL-4水平为15.23±2.17ng/L,明显低于对照组24.09±3.41ng/L。(4)观察组治疗后血清IFN-γ水平为13.58±1.75ng/L,明显优于对照组25.61±2.28ng/L。(5)观察组治疗后血清TNF-α水平为15.14±2.07ng/L,明显优于对照组27.59±3.65ng/L。(6)观察组治疗后CT检测结果异常率为46.67%,低于对照组63.33%,但差异无统计学意义。结论:黄芪注射液对脑瘫患儿的临床治疗效果确切,无明显副反应,值得临床进一步研究和应用。
Objective： To observe the clinical efficacy of Astragalus Injection combined with baclofen in treatment of children with cerebral palsy. Methods： 60 children with cerebral palsy from June 2013 to May 2015 were randomly divided into observation group with 30 cases and control group with 30 cases. The control group received baclofen treatment, and observation group were given Astragalus Injection treatment. 30 days for a course of treatment and two groups were treated for 6 courses. Related indicators of two groups were recorded and compared. Results ： （1）After treatment,the DQ and IQ score of observation group were （ 60.58 ± 5.38,65.57 ± 6.46 ） points, better than that of control group （51.36 ± 5.21,55.58 ± 6.05 ） points, and the difference was statistically significant （ p 〈 0.05）. （2）After treatment, the ADL score of observation group was （67.58 ± 6.30） points, better than that of control group （55.94 ± 6.14） points （p 〈 0.05 ）. （3）After treatment, the serum IL-4 levels of observation group was （ 15.23 ± 2.17 ） ng/L, higher than that of control group （ 24.09 ± 3.41 ） ng/L（ p 〈 0. 05 ）. （4） After treatment, serum IFN-α level of observation group was （ 13.58 ± 1.75 ） ng/L, better than that of control group（25.61± 2.28） ng/L（ p 〈 0.05）. （5）After treatment, serum TNF-α level of observation group was （ 15.14 ±2.07） ng/L,bctter than that of control group （27.59 ± 3. 6.5 ） ng/L（ p 〈 0.05 ）. （6）After treatment, abnormal rate of CT detection results of observation group was 46.67% , lower than that of control group 63.33% , but the difference was not significant（ p 〉 0.05 ）. Conclusion： Astragalus Injection has curative effect in treatment of children with cerebral palsy, no significant side effects and it is worthy of further research and application.
出处
《中药药理与临床》
CSCD
北大核心
2017年第3期190-193,共4页
Pharmacology and Clinics of Chinese Materia Medica
基金
国家自然科学基金面上项目(81072799)
关键词
黄芪注射液
巴氯芬
脑瘫
Astragalus Injection（黄芪注射液）
baclofen
cerebral palsy
medication contrast
