摘要
目的:探讨干扰素-γ(IFN-γ)、肿瘤坏死因子(TNF)-α及白细胞介素(IL)-6在脑瘫中的作用。方法:采用酶联免疫吸附法检测28例脑瘫患儿及15例正常儿童外周血单核细胞(PBMC)中IFN-γ、TNF-α及IL-6的水平。结果:脑瘫患儿PBMC中IFN-γ、TNF-α、IL-6分别为(46.17±14.29)pg/ml、(28.65±11.44)pg/ml、(67.13±21.10)pg/ml,对照组分别为(37.31±16.64)pg/ml、(18.43±10.97)pg/ml、(46.44±23.39)pg/ml,差异均有统计学意义(P<005)。结论:脑瘫患儿IFN-γ、TNF-α及IL-6水平的升高,可能与脑瘫的发生有关,即脑瘫的发生与免疫系统及其功能异常有密切关系。
Objective ：To investigate the role of interferon-γ （IFN-γ）.tumor necrosis factor-α （TNF-α）and interleukin-6 （IL-6） in children with cerebral palsy.Methods：The levels of IFN-γ,TNF-α and IL-6 in the peripheral blood mononuclear cells （PBMC） in 28 cases of cerebral palsy were detected by enzyme linked immunoabsorbent assay,and compared with those in 15 normal children.Results：Significant elevated levels of IFN-γ,TNF-α and IL-6 were found in PBMC in children with cerebral palsy（（46.17±14.29）pg/ml,（28.65±11.44） pg/ml and （67.13±21.10）pg/ml respectively）compared with those in normal children （（37.31±16.64）pg/ml,（18.43±10.97）pg/ml and （46±23.39）pg/ml respectively）,all differences were statistical significance （all P〈0.05）.Conclusion：The elevated levels of IFN-γ,TNF-α and IL-6 in PBMC in children with cerebral palsy may have relationship with the occurrence of cerebral palsy.That is,the occurrence of cerebral palsy is closely correlated with the functional abnormality of immunity.
出处
《现代医药卫生》
2005年第23期3207-3208,共2页
Journal of Modern Medicine & Health
