摘要
目的探讨不同胃黏膜病理表现与幽门螺杆菌(Helicobacter pylori,H.pylori)、血清胃蛋白酶原的相关性。方法收集复旦大学附属上海市第五人民医院2015年7月-2016年6月完成胃镜活检病理、H.pylori测定及胃蛋白酶原(pepsinogen,PG)检测的患者386例,并分析其相关性。结果胃黏膜病理与H.pylori感染无显著相关性(R=-0.084,P=0.100);胃黏膜病理与胃蛋白酶原Ⅰ(PGⅠ)无显著相关性(R=-0.003,P=0.949),与PGⅡ呈正相关(R=0.258,P=0.000),与胃蛋白酶原比值(PGR)呈负相关(R=-0.194,P=0.000);H.pylori与PGⅠ无显著相关性(R=-0.033,P=0.522),与PGⅡ呈负相关(R=-0.173,P=0.001),与PGR无显著相关性(R=0.093,P=0.069)。胃黏膜病理与癌胚抗原(CEA)呈正相关(R=0.146,P=0.004),与年龄无显著相关性(R=-0.004,P=0.930)。结论胃黏膜病理改变与H.pylori感染无显著相关性,与PGⅡ及CEA呈正相关,与PGR呈负相关,H.pylori与PGⅡ呈负相关,与PGR无相关性。
Objective To investigate the correlation of different gastric mucosal pathologic manifestations with Heli- cobacter pylori （H. pylori） and serum pepsinogen. Methods Three hundred and eighty-six patients who completed the endoscopy biopsy pathology, H. pylori pathology determination and pepsinogen （PG） detection were colleeted in the Fifth People＇s Hospital of Shanghai, Fudan University from Jul. 2015 to Jun. 2016, and the correlation was analyzed. Results Gastric mueosal pathology was not associated with H. pylori infection （R=- 0. 084, P = 0. 100）. Gastric mu- cosal pathology was not significantly correlated with pepsinogen [ （ PG I ） （R = - 0. 003, P -- 0. 949）, but was posi- tively correlated with PG Ⅱ （R = 0. 258, P = 0. 000） and negatively correlated with pepsinogen ratio （PGR） （R = -0. 194, P =0.000）. There was no significant correlation between H. pylori and PG I （R = -0. 033, P =0. 522） , but H. pylori was negatively correlated with PG I] （R= - O. 173, P = 0. 001 ）. Gastric mucosal pathology was positively correlated with CEA （R = 0. 146, P = 0. 004）, but not correlated with age （R = - 0. 004, P = 0. 930）. Conclusion Gastric mucosal pathological changes is not correlated with H. pylori infection, and positively correlated with PG Ⅱ and CEA, and negatively correlated with PGR, H. pylori is negatively correlated with PG Ⅱ , and not correlated with PGR.
出处
《胃肠病学和肝病学杂志》
CAS
2017年第8期918-920,共3页
Chinese Journal of Gastroenterology and Hepatology
关键词
幽门螺杆菌
胃蛋白酶原
胃黏膜病理
Helieobacter pylori
Pepsinogen
Gastric mucosal pathology
