摘要
目的单次大剂量丙种球蛋白在小儿重型ITP治疗中的的疗效观察。方法收集2016年2—9月青岛大学附属医院血液儿科收治的60例重症ITP的患儿临床资料,按照不同的治疗方案,分析3组患儿的临床疗效及不良反应发生率。结果观察大剂量组各血液指标改善时间(2.25±1.02)d短于小剂量组(3.42±1.18)d及对照组(7.22±2.31)d;大、小剂量组患儿总有效率(分别为95.00%、90.00%)均明显高于对照组(75.00%),差异有统计学意义(P<0.05);不良反应发生率(20.00%)明显低于对照组(50.00%),差异有统计学意义(P<0.05),与小剂量组(25.00%)比较差异无统计学意义(P>0.05)。结论单次大剂量丙种球蛋白能快速改善小儿重型ITP的出血症状及各血液指标,提高临床疗效,且安全性高,避免了激素的不良反应,值得临床推广。
Objective A single large dose of gamma globulin in the treatment of children with severe ITP in the clinical observation. Methods Collecting the clinical data of 60 patients with severe 1TP in children from February to Septem- ber 2016 of Affiliated Hospital of Qingdao University of pediatrics blood , according to the different treatment, analysis of clinical efficacy and incidence of adverse reactions in three groups of children. Results The high dose group the blood indexes improved time（2.25±1.02）days shorter than the low dose group（3.42±1.18）days and control group（7.22± 2.31）days;The high and low close groups＇the total effective rates （95.00% and 90.00%）were significantly higher than the control group （75.00%）, the difference was statistically significant （P 〈 0.05）;the incidence of adverse reaction （20.00%） Significantly lower than the control group（50.00%） had statistically significant difference （P 〈 0.05）, and the differences between the low dose group （25.00%） was not statistically significant （P 〉 0.05）. Conclusion The single large dose of gamma globulin can improve the symptoms of severe hemorrhage in children with ITP and the blood in- dexes, improve clinical curative effect, and high safety, avoid the adverse reaction, is worthy using in the clinical appli- cation.
作者
林清华
LIN Qing-hua(Affiliated Hospital of Qiingdao University of Pediatrics Blood ,Qingdao, Shandong Province 266000 China Depart- ment of Pediatries,Hich-teeh Industria Development District People＇s Hospital,Linyi,Shandong Province 276000 China)
出处
《系统医学》
2017年第2期79-81,共3页
Systems Medicine
关键词
丙种球蛋白
重型ITP
疗效
Immunoglobulin ,Severe ITP
Curative effect
