摘要
目的:观察静脉丙种球蛋白(IVIG)冲击治疗免疫性血小板减少症(immune thrombocytopenia,ITP)患儿对其血细胞计数的影响。方法:回顾性分析207例ITP患儿,根据治疗药物分为2组,观察组(n=101)给予IVIG1 g·kg-1·d-1冲击剂量1次,同时加用阿赛松1.6mg·kg-1·d-1口服和地塞米松0.2mg·kg-1·d-1静滴;对照组(n=106)仅给予阿赛松1.6mg·kg-1·d-1口服和地塞米松0.2mg·kg-1·d-1静滴。比较2组治疗前后血细胞计数的变化,并对其进行统计学分析。结果:在治疗前2组中性粒细胞计数差异没有统计学意义,而在治疗后2d观察组中性粒细胞计数下降,与对照组相比有统计学意义(P=0.001);治疗后2组发生溶血性贫血、中性粒细胞减少症、淋巴细胞减少症及单核细胞减少症的人数观察组均显著高于对照组,差异均有统计学意义(P=0.001)。结论:IVIG冲击治疗ITP可以观察到多种血液细胞成分数量下降,认为与其细胞毒性有关。
OBJECTIVE To observe the effects of high dose intravenous immunoglobulin G（IVIG）on blood cell count in infants and children with immune thrombocytopenia.METHODS A total of 207 infants and children with immune thrombocytopenia were retrospectively divided into two groups according to therapeutic drugs.The treatment group（n=101）received a high dose of IVIG（1 g·kg^-1·d^-1）with triamcinolone（1.6 mg·kg^-1·d^-1）and dexamethasone（0.2 mg·kg^-1·d^-1）The control group only received triamcinolone（1.6 mg·kg^-1·d^-1 and dexamethasone（0.2 mg·kg^-1·d^-1）Complete blood counts were compared between the two groups before and after treatment,and analyzed statistically.RESULTS Neutrophil counts of the two groups had no statistically significant difference.After two days,neutrophil count of treatment group was more than control group,with statistical significance（P=0.001）.Furthermore,incidences of hemolytic anemia,neutropenia,lymphocytopenia and monocytopenia in treatment group were also higher than in control group（P=0.001）.CONCLUSION We have observed a transient decrease of blood cell count,which should be associated with toxicity on blood cells of high dose IVIG.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2015年第5期435-437,共3页
Chinese Journal of Hospital Pharmacy
