摘要
α-葡萄糖苷酶抑制剂是20世纪70年代后期研究开发出来的一类新型口服降血糖药物,通过降低餐后血糖浓度,有效控制血糖水平,从而减少糖尿病并发症的发生。研究表明,植物次生代谢产物具有丰富的生物学功能,如降血糖、降血脂、抗肿瘤、增强机体免疫力等。该文对具有抑制α-葡萄糖苷酶活性作用的植物次生代谢产物的来源及其作用机制进行了综述。旨在为寻求安全、高效的植物次生代谢产物来源的α-葡萄糖苷酶抑制剂提供参考。
α-Glucosidase inhibitor was a new type of antidiabetics which was developed in the late 1970s. By reducing the post- prandial blood sugar concentration, it could effectively control the blood sugar levels, thereby reducing the occurrence of diabetic com- plications. Studies have shown that plant secondary metabolites have important biological functions such as hpyerglycemic, anti-hyper- lipidemia, immunomodulatory, and antitumor effects. In this paper, the sources of plant secondary metabolites which are able to inhibit α-glucosidase and their inhibition mechanism would be reviewed to provide references for seeking more safe and efficient plant seconda- ry metabolites of α-glucosidase inhibitors.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2017年第15期2915-2924,共10页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(31560459
31160319)
江西省高等学校科技落地计划项目(KJLD13027
GJJ13281)
广东省农产品加工重点实验室开放基金(201603)
江西省研究生创新专项资金项目(YC2016-S186)
