摘要
目的:检测系统性红斑狼疮(Systemic lupus erythematosus,SLE)患者血清白细胞介素(Interleukin,IL)-34水平,并进一步探讨IL-34与临床和实验室指标及SLE疾病活动度的关系。方法:采用酶联免疫吸附试验(Enzyme-linked immunosorbent assay,ELISA)测定78例SLE组及53名正常对照组血清IL-34水平,SLE组与正常组血清IL-34水平分析采用曼-惠特尼U检验(Mann-Whitney U test)。结果:与正常对照相比,SLE组血清IL-34水平明显高于正常对照组[(Median,128.9 pg/ml)vs(Median,52.4 pg/ml),P<0.001],差异有统计学意义。IL-34水平与SLE疾病活动度、双链DNA抗体(anti-double stranded DNA antibody,anti-ds DNA)滴度、C反应蛋白(C-reactive protein,CRP)呈正相关,与C3水平呈负相关。结论:血清IL-34可能成为SLE的一血清标志物,因其在SLE患者中升高,且与疾病活动度相关。
Objective ： To investigate levels of serum IL-34 in SLE patients,and correlation between concentrations of serum IL- 34 and other established serum markers and disease activity indexes. Methods ： In all,78 SLE patients and 53 healthy controls were enrolled in the research. Enzyme-linked immunosorbent assay（ ELISA） was employed to measuring the concentrations of serological IL- 34. Then,serum IL-34 levels between SLE group and healthy controls were analyzed by Mann-Whitney U test. Meanwhile, the correlation between the serum IL-34 levels and disease activity indexes and other established serum markers were assessed. Serum IL-34 levels were significantly higher in SLE patients compared to healthy controls[（Median,128. 9 pg /ml） vs （Median,52. 4 pg /ml）, P〈0. 001]. Results： Their levels were remarkably associated with accumulation of the clinical features of SLE. Additionally, IL-34 titers were positively correlated with the SLE disease activity indexes, anti-double stranded DNA antibody （ anti- dsDNA） titers and C-reactive protein（CRP）levels,but inversely with C3 levels. Conclusion： Serum IL-34 could be a candidate biomarker for SLE as the elevated serum levels in treatment-naive SLE patients and its association with SLE disease activity.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2017年第8期1232-1235,共4页
Chinese Journal of Immunology
