摘要
胃癌是发生于胃黏膜上皮的一种恶性肿瘤,是全世界恶性肿瘤中较为常见的一种。胃癌的诊断、预后、远期生存预测、转移及复发与一些生物学标志物有明显的相关性。因此,寻找一种敏感性较高、特异性较强的生物学标志物显得尤为重要。临床广泛使用的肿瘤标志物检测可协助胃癌的诊断,以早期发现胃癌,降低病死率,改善患者预后。目前人类表皮生长因子受体2、上皮钙黏素、肝细胞生长因子受体、微RNA均为热门胃癌生物学标志物。
Gastric cancer is a malignant tumor occurring in gastric mucosal epithelium and is a common type of malignant tumor in the world.The diagnosis,prognosis,long-term survival,metastasis and recurrence of gastric cancer are significantly correlated with some biological markers.Therefore,looking for a strong biological marker with high sensitivity and specificity is particularly important.The clinical use of tumor markers can improve the diagnosis of gastric cancer,in order to achieve early detection of gastric cancer,reduce the case fatality rate,and improve the prognosis of patients.At present, human epidermal growth factor receptor2,E- cadherin,hepatocyte growth factor receptor,and microRNA are popular gastric cancer biomarkers.
作者
莫丽蓉
杨金芳
李雪
虎金鹏
周燕
白飞虎
MO Lirong;YANG Jinfang;LI Xue;HU Jinpeng;ZHOU Yan;BAI Feihu(Ningxia Medical University,the Third Clinical Medical College, Yinchuan 750000,China;Department of Gastroenterology,Ningxia Hui Autonomous Region People′s Hospital,Yinchuan 750001,China)
出处
《医学综述》
2019年第7期1327-1331,1337,共6页
Medical Recapitulate
基金
国家自然科学基金(81360323)
关键词
胃癌
肿瘤标志物
生物学
Gastric cancer
Tumor markers
Biology
