摘要
目的:探讨白介素17F(IL-17F)基因多态性rs763780和rs2397084与类风湿关节炎(RA)易感性的关系。方法:计算机检索中国学术期刊全文数据库、万方数据库、中国生物医学文献数据库、Pubmed、Embase以及Web of Science中已发表的与RA和IL-17F基因多态性相关文献,进行Meta分析。结果:纳入的5项研究共收集RA患者1 174例(其中rs763780含1 174例,rs2397084含985例),正常对照966例(rs763780含966例,rs2397084含766例)。Meta分析结果显示,rs763780与RA密切相关(C vs.T:OR=1.74,95%CI=1.01-2.98,P=0.04;CC vs.TT:OR=3.17,95%CI=1.21-8.35,P=0.02;CT vs.TT:OR=1.80,95%CI=1.21-2.66,P=0.004;CC+CT vs.TT:OR=1.96,95%CI=1.35-2.83,P<0.001;CC vs.CT+TT:OR=2.97,95%CI=1.13-2.66,P=0.03)。根据人种进行亚组分析发现,在欧洲人群中rs763780与RA密切相关,差异具有统计学意义。未发现rs2397084与RA之间的相关性。结论:IL-17F rs763780是RA的危险因素,IL-17F rs2397084与RA易感性是否有关仍不明确。
Objective ：To explore the association between rheumatoid arthritis（RA）and two polymorphisms of interleukin-17 （IL-17F）rs 763780 and rs 2397084. Methods： A systematic search of relevant studies was conducted in China National Knowledge In-frastructure, Wanfang Chinese Periodical Database,China Biology Medical Literature Database, Pubmed, Embase and Web of Science. Results： A total of 5 case-control studies including 1 174 RA cases and 966 health controls for rs 763780 and 985 RA cases and 766 health controls for rs 2397084 were included in this Meta- analysis. The results showed that rs 763780 was significantly associated with increased susceptibility to RA（C vs. T： OR=1. 74,95% CI =1. 01-2. 98, P = 0. 04;CC vs. TT：OR = 3. 17,95% CI =1. 21-8. 35, P = 0.02;CT vs.TT：OR = 1.80,95% CI =1.21-2.66, P = 0.004;CC ＋ CT vs.TT：OR = 1.96,95% Cl = 1.35-2.83, P〈0.001;CC vs. CT＋ TT：OR = 2. 97,95% CI =1. 13-2. 66, P = 0.03）. In subgroup analysis based on ethnicity, rs 763780 was positively correlated with RA in Europeans. No significant association was found between rs 2397084 and RA. Conclusion： The present study revealed that IL-17F rs 763780 polymorphism is a risk factor of RA,while the association of rs 2397084 with RA remains uncertain.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2017年第8期1218-1222,共5页
Chinese Journal of Immunology
