摘要
目的探讨抗菌肽RISE-AP12联合中药汤剂治疗对种植体周围炎龈沟液炎症因子的影响。方法选择2010年3月至2015年10月医院收治的种植体周围炎患者80例(种植体146枚),按随机数字表法分为观察组和对照组,各40例(种植体各73枚)。两组患者均行牙周基础治疗,双氧水漱口,盐酸米诺环素软膏留置,每周1次治疗,4周为1疗程,连续治疗2个疗程;口服中药汤剂,每日2次,4周为1个疗程,连续治疗2个疗程。观察组患者在此基础上加用抗菌肽RISE-AP12含漱,每日3次。结果治疗后,两组患者菌斑指数(PLI)、探诊深度(PD)和龈沟出血指数(SBI)水平均降低,且观察组降低更明显(P<0.05)。两组患者龈沟液中白细胞介素6(IL-6)、一氧化氮合酶(NO)、基质金属蛋白酶2(MMP-2)表达均降低,且观察组降低更明显(P<0.05)。两组患者可溶性血管黏附分子1(s VCAM-1)、E型钙黏附分子(E-cadherin)均降低,骨保护因子(OPG)均升高,且观察组变化更优(P<0.05)。虽观察组总不良反应发生率高于对照组(P<0.05),但症状均较轻微,不影响治疗。结论抗菌肽RISE-AP12联合中药牙周基础治疗可显著改善种植体周围炎患者的临床体征,并显著降低患者龈沟液中炎症因子、黏附因子表达,促进OPG表达,不良反应均轻微,经对症处理后不影响治疗,值得临床推广。
Objective To investigate the effect of Antibacterial Peptide RISE-AP12 combined with traditional Chinese medicine（ TCM）decoction on inflammatory factors in peri-implant crevicular fluid. Methods 80 patients（ 146 implants） with periimplantitis admitted to our hospital from March 2010 to October 2015 were randomly divided into the observation group and the control group, 40 cases（ 73 implants） in each group. The patients in the two groups were given periodontal treatment,hydrogen peroxide mouthwash,minocycline hydrochloride ointment lien, once weekly treatment for 4 weeks as a course of treatment, continuous treatment for 2 courses, at the same time, the patients were given TCM decoction,4 weeks as a course of treatment, continuous treatment for 2 courses, on this basis, the observation group was treated with Antimicrobial Peptide RISE-AP12 gargle, 3 times/d. Results After treatment, The PLI, PD, SBI levels in the two groups were significantly decreased,and the observation group decreased more significantly（ P〈0. 05）. After treatment,the expression of IL-6,NO,MMP-2 in the two groups were significantly decreased,and the observation group decreased more significantly（ P〈0. 05）. After treatment, the s VCAM-1, E-cadherin in the two groups were significantly decreased, but OPG were significantly increased, and the observation group improved more significantly（ P〈0. 05）. The incidence of adverse reactions in the observation group was higher than that in the control group（ P〈0. 05）, but the symptoms were mild and did not affect the treatment.Conclusion Antibacterial Peptide RISE-AP12 combined with TCM decoction can significantly improved clinical signs of patients with periimplantitis, significantly decreased the expression of inflammatory factors and adhesion factors in peri-implant crevicular fluid and promote the expression of osteoprotegerin, the adverse reactions are mild and it does not affect the treatment after symptomatic treatment,it is worthy of clinical promotion.
作者
董颖韬
贾斌
Dong Yingtao Jia Bin(Chongwen Stomatological Hospital, Beijing, China 100062)
出处
《中国药业》
CAS
2017年第11期60-63,共4页
China Pharmaceuticals
关键词
抗菌肽RISE-AP12
中药
种植体周围炎
牙周基础治疗
龈沟液
炎症因子
Antibacterial Peptide RISE-AP12
traditional Chinese medicine
periimplantitis
initial periodontal therapy
grevicular fluid
inflammatory factors
