摘要
目的探讨中西医结合治疗老年冠状动脉粥样硬化性心脏病(简称冠心病)的疗效及对血脂水平的影响。方法选取2014年3月至2015年6月医院收治的老年冠心病患者83例,按随机数字表法分为中西医组(42例)和西药组(41例)。西药组患者给予阿托伐他汀治疗,每次20 mg,1次/日;中西医组在西药组基础上给予益气活血中药治疗。两组均以2周为1个疗程,连续治疗2个疗程。观察两组血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平,比较两组疗效、不良反应发生情况,出院后随访3个月、6个月,比较两组复发率。结果中西医组治疗总有效率为95.24%,显著高于西药组的73.17%(P<0.05);中西医组心电图有效率为92.86%,显著高于西药组的75.61%(P<0.05)。治疗后,两组TC,TG,LDL-C水平均较治疗前降低(P<0.05),HDL-C无明显变化,且中西医组TC,TG,LDL-C水平降幅大于西药组(P<0.05);中西医组在出院后3个月、6个月的复发率均较西药组低(P<0.05)。治疗期间,西药组3例出现便秘、腹胀、腹痛等症状,停药后好转;中西医组未见明显不良反应发生。结论中西医结合联合用药治疗老年冠心病患者,能有效改善临床症状,提高血脂达标率及生活质量。
Objective To investigate the effect of traditional Chinese medicine （ TCM ） and western medicine in the treatment of coronary heart disease in elderly patients and its effect on blood lipid level. Methods Totally 83 elderly patients with coronary heart disease in our hospital from March 2014 to June 2015 were randomly divided into the TCM and western medicine group （ n=42 ） and western medicine group （ n=41 ） according to the random number method. The western medicine group was treated with atorvastatin, 20 mg/times, 1 times/d, on this basis, the TCM and western medicine group was treated with TCM decoction. 2 weeks as 1 course of treatment, continuous treatment of 2 courses. The levels of TC, TG, LDL-C, HDL-C were observed, the curative effect, adverse reaction were compared between the two groups, and the recurrence rate was compared between the two groups after followed up for 3, 6 months. Results The total effective rate of the TCM and western medicine group was 95. 24%, which was significantly higher than 73. 17% of the western medicine group （ P 〈 0. 05 ） . After treatment, the effective ECG rate of the TCM and western medicine group was 92. 86%, which was significantly higher than 75. 61% of the western medicine group （ P 〈 0. 05 ） . The levels of TC, TG and LDL-C in the two groups were significantly lower than those before treatment （ P 〈 0. 05 ） , but there was no obvious change in HDL-C, and the levels of TC, TG and LDL-C in the TCM and western medicine group were significantly lower than those in the western medicine group （ P 〈0. 05 ） . The recurrence rate of the TCM and western medicine group was significantly lower than that of the western medicine group at 3, 6 months after discharge （ P 〈 0. 05 ） . During the treatment period, 3 cases in the western medicine group showed constipation, abdominal distension, abdominal pain and other symptoms, and improved after the withdrawal, but there was no obvious adverse reaction in the TCM and western medicine group. C
作者
李慧敏
余娟
刘莉娟
Li Huimin Yu Juan Liu Lijuan(Center Heart of the Ninth People＇s Hospital of Zhengzhou, Zhengzhou, Henaa, China 45000)
出处
《中国药业》
CAS
2017年第13期47-49,共3页
China Pharmaceuticals
关键词
老年
冠状动脉粥样硬化性心脏病
中西医结合
血脂
临床疗效
elderly
coronary heart disease
combination of TCM and western medicine
blood lipid
curative effect
