摘要
目的观察氯雷他定联合孟鲁司特片治疗变应性鼻炎,和单独使用氯雷他定治疗对患儿鼻塞症状的临床疗效差异。方法将门诊就诊的变应性鼻炎的患儿80例随机分到治疗组(氯雷他定联合孟鲁司特片)和对照组(氯雷他定片),每组各40例。治疗组给予氯雷他定片,5mg或10mg,孟鲁司特片,4mg或5mg,每天均口服1次;对照组给予氯雷他定片,5mg或10mg,每天1次。连续治疗14天。疗程第7天、第14天采用视觉模拟量表(Visual Analog Scale,VAS)进行鼻部症状评分和鼻塞症状评分。结果共有76例患儿完成观察期,并纳入疗效分析,其中治疗组(38例)及对照组(38例)。两组鼻部症状VAS评分进而鼻塞症状VAS评分在治疗第7天(P<0.05)、第14天均较治疗前明显下降(P<0.01)。治疗第7天和第14天两组鼻部症状和鼻塞症状VAS评分有显著性差异(P<0.05)。结论氯雷他定联合孟鲁司特片较之单独使用氯雷他定片,可更加有效控制过敏性鼻炎鼻塞症状。
Objective To observe the effects of loratadine combined with montelukast tablet on relieving nasal congestion compared to loratadine alone in children with allergic rhinitis. Methods children with allergic rhinitis were divided randomly into two groups, the treatment group which treated with loratadine combined with montelukast tablet, and the control group which treated with loratadine alone. The dosage of montelukas is 4 or 5 mg once daily;The dosage of loratadine is 5 or 10 mg, once daily. The course of treatment is 14 days. In the fourteenth day, The visual analog scale （VAS） was given to grade the nasal symptoms and nasal congestion. Results A total of 76 children finished the experiment, and 38 cases in each group. VAS of nasal symptoms and nasal congestion decreased significantly in both groups on 7th （P〈0.05） and 14th （P〈0.05）. There were significant differences for the VAS of nasal symptoms and nasal congestion between the two groups on 7th and 14th （both P〈0.05）. Conclusion Loratadine combined with montelukast tablet are more effective on relieving the nasal congestion in children with allergic rhinitis when compared to loratadine alone.
出处
《中国中西医结合耳鼻咽喉科杂志》
2017年第3期193-195,共3页
Chinese Journal of Otorhinolaryngology in Integrative Medicine
关键词
氯雷他定联合孟鲁司特片
变应性鼻炎患儿
鼻塞症状
Loratadine combined with montelukast
Children with allergic rhinitis
nasal congestion
