摘要
"拯救脓毒症运动(Surviving Sepsis Campaign)"指南的提出,显著降低了脓毒症患者早期病死率,结果确实让人欣慰。然而脓毒症患者的远期预后不容乐观,患者3年内死亡率、精神/生理功能和经济负担等方面均存在严重问题,成为脓毒症治疗新的挑战,当前已明确影响脓毒症远期结局的主要问题为"持续炎症、免疫抑制和分解代谢综合征(PICS)",文中从PICS概念的提出、发生机制、治疗策略等方面展开系统综述,为脓毒症的诊疗提供新的思路。
The early mortality of sepsis patients has been largely decreased since the publication of the Surviving Sepsis Campaign guidelines. However,the poor long-term prognosis,high 3-year mortality,impaired mental and physical functions,and tremendous financial burden constitute a new challenge to the treatment of sepsis. Persistent inflammation immuno-suppression catabolism syndrome（ PICS） is known to be a definite factor affecting the long-term prognosis of sepsis. This article presents a systematic review of the concept,pathogenesis and treatment strategies of PICS,hoping to provide a new approach to the diagnosis and management of sepsis.
出处
《医学研究生学报》
CAS
北大核心
2017年第7期673-677,共5页
Journal of Medical Postgraduates
关键词
脓毒症
持续炎症、免疫抑制和分解代谢综合征
慢性危重症
免疫治疗
Sepsis
Persistent inflammation immuno-suppression catabolism syndrome
Chronic critical illness
Immunotherapy
