摘要
巡逻单核细胞(PMo)是单核细胞的一个亚群,其主要功能是在血管内巡逻,清除微循环中的细胞碎片。研究发现PMo还参与抗肿瘤反应,抑制肿瘤细胞生长,招募自然杀伤细胞(NK)杀伤肿瘤细胞,并防止肿瘤细胞血行转移至肺,起着免疫监视的作用。PMo或许可以成为肿瘤免疫治疗的靶标。
Patrolling monocyte (PMo) is a subset of monocytes. Its main function is patrolling vascular endothelium and removing cellular debris from the microvasculature. Studies have revealed that PMo can inhibit the growth of tumor cells, recruiting NK cells to kill tumor cells. PMo can prevent tumor cells metastasis to the lung, which plays a role of immunosurveillanee. PMo may be a target for cancer immunotherapy.
作者
方萍
徐可
陈彬
高虹
朱晏伟
Fang Ping Xu Ke Chen Bin Gao Hong Zhu Yanwei.(Department of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, Chin)
出处
《国际肿瘤学杂志》
CAS
2017年第5期366-368,共3页
Journal of International Oncology
基金
国家自然科学基金(81503434)
关键词
肿瘤
免疫
单核细胞
Neoplasms
Immune
Monocytes