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白介素-1β在炎性痛中的作用及其机制 被引量:30

Roles and mechanisms of interleukin-1β during inflammatory pain
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摘要 促炎细胞因子在许多病理状态下,如炎症、神经系统损伤、癌症等,对疼痛和痛觉过敏的发生和维持有重要作用。目前得到普遍认可的促炎细胞因子有IL-1β、IL-6、TNF-α,该文就IL-1β在炎性疼痛中的作用及其可能的外周、中枢机制作一综述。 Numerous studies have shown that pro-inflammatory cytokines induce or facilitate pain and hyperalgesia in the presence of inflammation,injury to the nervous system or cancer.At present,generally accepted pro-inflammatory cytokines are IL-1β,IL-6,TNF-α.This review outlines the recent findings of IL-1β in inflammatory pain and its possible peripheral and central mechanisms for the effects of IL-1β in nociceptive transmission.
出处 《生命科学》 CSCD 北大核心 2010年第3期291-295,共5页 Chinese Bulletin of Life Sciences
基金 国家自然科学基金项目(30970985) 福建省自然科学基金项目(C0710005) 福建师范大学优秀青年骨干教师培养基金项目(2008100238)
关键词 白介素-1Β 炎性痛 痛觉过敏 interleukin-1β inflammatory pain hyperalgesia
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