摘要
上皮间质转化(epithelialmesenchymal transition,EMT)是一个动态的、可逆的过程,可以促进组织发育、伤口愈合以及恶性上皮肿瘤发生、侵袭和转移,已成为当前研究的热点.Smads蛋白作为细胞内重要的信号转导蛋白,直接参与转化生长因子-β1(transforming growth factorβ1,TGF-β1)超家族中许多成员的信号转导,发挥调节细胞增殖、分化、迁移、凋亡等多种生物学活动.随着对Smads蛋白结构与功能的不断认识,日渐发现由Smads参与的TGF-β1/Smads通路所介导的EMT与人类的某些疾病(器官组织纤维化、肥厚性疤痕以及癌症等)密切相关.本文简要综述了Smads蛋白在TGF-β1/Smads通路介导EMT中的作用,以期对Smads参与调控EMT有更进一步的认识.
Epithelial mesenchymal transition （EMT） is a dynamic, reversible process. It can improve tissue development and wound healing and promote the development, invasion, and metastasis of malignant epithelial tumors. Smads, major signal transducer proteins in cells, play a direct role in signal transduction of many members of the transforming growth factor β1 （TGF-β1） superfamily, and have many biological activities, such as regulating cell proliferation, differentiation, migration, and apoptosis. Now, we have had a better understanding of the structures and functions of Smads, and they are supposed to be associated with TGF-β1/Smads-mediated EMT and the development of some diseases in humans, such as organ fibrosis, hypertrophic scar, and cancer. This review elaborates the roles of Smads in regulating TGF-β1/Smads- mediated EMT, aiming to make a further understanding of the mechanism of Smads in regulating EMT.
作者
李涛
周竞
吴焕淦
施茵
Tao Li ling Zhou Huan-Gan Wu Yin Shi(Yueyang Clinical Medical School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China Shanghai Institute of Acupuncture- Moxibustion and Meridian, Shanghai 200030, China)
出处
《世界华人消化杂志》
CAS
2017年第17期1572-1578,共7页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
Nos.81473757
81674069
国家重点基础研究发展计划(973计划)基金资助项目
No.2015CB554500~~
