摘要
肝癌在世界范围内属于高发病,且其恶性程度及死亡率均较高,肝癌前病变期是肝癌向恶性转变的重要过渡期。如果能了解该期的病变过程,并对其进行干预将大大降低肝癌的发生。研究发现,中药活性成分对其有很好地干预作用,且在肝癌前病变发生发展中存在多种信号通路的异常。文章通过查找与肝癌前病变发生的相关信号通路及其针对不同信号通路作用的中药活性成分,并对其进行探索总结。发现在对肝癌前病变发生发展中存在NF-κB信号通路、TGF-β/Smads信号通路、Wnt信号通路和Hedgehog信号通路的异常以及中药活性成分姜黄素、羟基红花黄色素A、黄芪总苷与多糖、丹酚酸等可以通过不同的信号通路发挥抑制肝癌前病变发生发展的作用。希望为临床治疗肝癌前病变、阻止其发展成为肝癌提供伦理依据。
Liver cancer,with a high incidence in the world,has high malignant degree and mortality.The precancerous stage is an important transition period for the malignant transformation of liver cancer.If we can understand the lesion process and intervene it,the incidence of liver cancer would be greatly reduced.It is found that active ingredients of Chinese medicine have a good intervention effect and there are many signal pathways in the development of precancerous lesions.In this paper,we searched and sunnarized the related signaling pathways and the active components of Chinese medicine for different signal pathways.It is found that NF-kappa B signaling pathway,TGF-beta/Smads signaling pathway,Wnt signaling pathway and Hedgehog signaling pathway are abnormal in the occurence and development of precancerous lesions.Besides,the active ingredients curcumin,hydroxysafflower yellow A,Astragalus glycosides and salvianolic acid play a role in inhibiting the occurrence and development in liver precancerous lesion through different signal pathways.It is hoped that it will provide ethical basis for clinical treatment of precancerous lesions of liver cancer and preventing it from developing into liver cancer.
作者
芮冉
董夏
孟博博
焦佩娟
方艳
潘艳芳
应小平
RUI Ran;DONG Xia;MENG Bobo;JIAO Peijuan;FANG Yan;PAN Yanfang;YING Xiaping(Graduate Students of Shaanxi University of Traditional Chinese Medicine,Xianyan 710046,Shaanxi,China;Department of Pathology,Shaanxi University of Traditional Chinese Medicine,Xianyan 710046,Shaanxi,China)
出处
《辽宁中医杂志》
CAS
2019年第5期1114-1116,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
陕西省中管局科研计划项目(15-LC002)
国家自然科学基金青年项目(81703842)
陕西省科技厅项目(2017SF-306)
关键词
肝癌前病变
发生发展
信号通路
中药活性成分
precancerous lesions
occurrence and development
signaling pathways
active components of traditional Chinese medicine
