摘要
多聚嘧啶通道结合蛋白1（PTBP1）是调控可变剪接及mRNA代谢过程中的重要蛋白.它的异常表达可造成其下游靶基因的可变剪接及mRNA水平的改变,直接参与肿瘤的发生、发展.PTBP1是具有很大潜力的肿瘤标志蛋白.
Polypyrimidine tract-binding protein 1 （PTBP1） is involved in almost all steps of mRNA metabolism,including alternative splicing due to its RNA-binding activity.PTBP1 regulates alternative splicing and levels of mRNA of its target genes,which directly contributes to the malignant phenotype during tumorigenesis.PTBP1 is a potential tumor markers for cancer diagnosis.
出处
《肿瘤研究与临床》
CAS
2015年第5期358-360,共3页
Cancer Research and Clinic
关键词
肿瘤
多聚嘧啶通道结合蛋白1
可变剪接
Neoplasms
Polypyrimidine tract-binding protein 1
Alternative splicing
