摘要
众所周知,冠心病的发生发展是基因、环境等众多因素共同作用的结果。目前的研究提出大概50%的冠心病源于基因异常。近些年,全基因组相关联研究(genome-wide association study,GWAS)取得了重大突破,研究证实染色体9p21与冠心病发病相关,目前已报道的研究,主要集中于欧洲人群或亚洲其他地区人群。很少有研究针对中国人群中该区域多态性与冠心病之间的关系进行较为系统的综述。这篇综述主要总结了在中国人群中9p21区域的基因多态性与冠心病目前的研究现状,并提出了未来的研究方向。
It is well known that the occurrence and development of coronary heart disease is the result of many factors, such as genes, environment and so on. The current study suggests that about 50% of coronary heart disease is due to genetic factors. In recent years, genome-wide association study, GWAS has made a major breakthrough, studies confirmed that the pathogenesis of chromosome 9p21 and coronary heart disease, the research has been reported, mainly concentrated in Europe or other Asian area population population. Few studies have systematically reviewed the relationship between the region polymorphism and coronary heart disease in Chinese population. This systematic review summarizes the current research status of ＂SNP＂ and ＂coronary heart disease＂ in Chinese population, and puts forward the future research direction of 9P21.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2017年第6期526-530,共5页
Journal of Clinical Cardiology
基金
国家自然科学基金项目(No:51572297)
关键词
基因多态性
冠心病
染色体9P21
gene polymorphism, coronary heart disease, chromosome 9p21
