摘要
线粒体替代疗法的主要应用方向为阻断线粒体基因病的遗传和改善高龄妇女的卵母细胞质量。线粒体基因病是线粒体基因组发生基因突变所导致的一类疾病,目前仍无治愈方法,线粒体替代疗法通过对含有突变型线粒体的卵母细胞进行线粒体置换,可阻断线粒体遗传病向子代传递。此外,线粒体替代或补充能增加老化卵母细胞的能量供应,有望用于改善高育龄妇女辅助生殖的临床结局。本文对线粒体替代疗法的研究进展及存在的问题进行综述。
Mitochondrial replacement therapy （MRT） is mainly used for eliminating transmission of mutant mitochondrial DNA （mtDNA） to offspring and improving the quality of oocytes of older women. MtDNA mutations are a relatively common cause of mitochondria disorders, there is currently no cure for these disorders. MRT is a process that the nuclear DNA is moved from oocyte or zygote with abnormal mtDNA then transferred into donor oocyte or zygote containing healthy mitochondria. MRT could prevent transmission of mtDNA disease to offspring. MRT can also increase mitochondrial function and energy supply in aged oocyte. It is suggested that mitochondrial transfers could have a positive impact on pregnancy outcome of assisted reproductive technology （ART） in older women. In this paper, the research progress and controversies of mitochondrial replacement therapies were reviewed.
出处
《中华生殖与避孕杂志》
CAS
CSCD
北大核心
2017年第5期407-411,共5页
Chinese Journal of Reproduction and Contraception
