摘要
随着我国"二孩"政策的放开,越来越多的高龄女性有生育要求,但高龄女性常有低妊娠率、高流产率等生育力低下的问题。高龄对女性最主要的影响体现在卵巢老化,主要表现为卵母细胞数量减少和卵母细胞质量下降,这两方面都是随着年龄进展的自然生理现象,但卵母细胞质量下降的原因较为复杂,主要可以概括为染色体非整倍体率增加、线粒体功能减退、端粒变短和端粒酶活性下降、超微结构改变等几方面。而改善卵母细胞质量的方法主要包括添加辅助药物及自体生殖系线粒体移植。
With the release of the two-child policy, there will be more and more elder women who want to have the second child facing the decline of fertility. The advanced age usually leads to oocyte aging, which mainly reduces the number and the quality of oocytes. These two aspects are natural physiological phenomena developed with age. The reasons of oocyte quality decline are complicated, which can be concluded into four parts： the increase of aneuploid, the mitochondrial dysfunction, the telomere shorten and decline of telomerase activity, the ultrastructural changes. The current therapies to improve oocyte quality include medicine addition and autologous germline mitochondrial energy transfer.
出处
《生殖与避孕》
CAS
CSCD
北大核心
2016年第9期752-757,共6页
Reproduction and Contraception
基金
深圳市科技研发资金基础研究计划面上项目,项目号:JCYJ20120616144719076
关键词
高龄
卵母细胞质量
非整倍体
线粒体
端粒
治疗对策
advanced age
oocyte quality
aneuploid
mitochondrial
telomere
treatment strategy
