摘要
干燥综合征(Sj?gren’s syndrome,SS)是一种以侵犯泪腺、唾液腺等外分泌腺体为特征的弥漫性结缔组织病,肝损害是常见的并发症之一。导致肝损害的原因多种多样,普遍认为是由于淋巴细胞和浆细胞对肝汇管区的浸润,引起体液免疫和细胞免疫异常,释放各种炎性介质而造成组织炎症和破坏,其临床表现缺乏特异性。SS与自身免疫性肝病关系十分密切,目前对于这两种肝损害在临床上并无统一结论。糖皮质激素通常可迅速改善临床症状和实验室检查指标,对于病情进展迅速者可合用免疫抑制剂,利妥昔单抗治疗SS肝损害的相关研究较少,熊去氧胆酸常用于治疗SS合并原发性胆汁性肝硬化。
Sjogren＇s syndrome （SS） is a connective tissue disease characterized by the invasion to lacrimal glands and salivary glands. Liver damage is one of the common complications. There are many causes and it is generally believed that the pathogenesis is due to the infiltration of lyrnphocytes and plasmocyte to the hepatic portal, which leads to humoral and cellular immune abnormalities, releasing a variety of inflammatory mediators to cause tissue inflammation and destruction. Clinical manifestations are not specific. SS is closely related to autoimmune liver disease, but there is no unified conclusion about these two kinds of liver damage at present. Corticosteroids can quickly improve clinical symptoms and laboratory results. Immunosuppressant can be used in patients with rapid progression. Few studies have been done on the effects of rituximab on SS liver damage. Ursodeoxycholic acid is commonly used in the treatment of SS complicated with primary biliary cirrhosis.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2017年第6期496-498,共3页
Chinese Journal of Practical Internal Medicine
基金
辽宁省科学计划项目(2014225017)
