摘要
目的:观察熊去氧胆酸联合泼尼松龙治疗原发性胆汁性肝硬化合并干燥综合征的临床效果。方法:130例原发性胆汁性肝硬化合并干燥综合征患者随机均分为对照组和观察组,对照组采用单纯熊去氧胆酸治疗,观察组采用熊去氧胆酸联合泼尼松龙治疗;比较两组患者治疗前、治疗后3个月时的口干、乏力、眼干及瘙痒等症状发生率,同时检测患者血清谷丙转氨酶(ALT)、天冬氨酸转氨酶(AST)、酸性磷酸酶(ALP)、总胆红素(TBil)、直接胆红素(DBil)等肝功能指标,检测患者血浆白蛋白(ALB)、免疫球蛋白G(Ig G)、免疫球蛋白M(Ig M)及免疫球蛋白A(Ig A)水平。结果:治疗前,两组患者临床症状发生率、肝功能指标和免疫球蛋白指标比较,差异无统计学意义(P>0.05);治疗3个月时,观察组出现乏力、瘙痒、眼干及口干症状的发生率低于对照组,所检测的肝功能指标低于对照组,ALB高于对照组,Ig G、Ig M及Ig A低于对照组,差异有统计学意义(P<0.05)。结论:熊去氧胆酸联合泼尼松龙治疗原发性胆汁性肝硬化合并干燥综合征效果优于单一的熊去氧胆酸治疗,可改善患者部份肝功能和免疫球蛋白指标。
Objective：To investigate clinical effect of ursodeoxycholic acid combined with prednisolone on primary biliary cirrhosis with sjogren syndrome.Methods：130 patients diagnosed with primary biliary cirrhosis complicated Sjogren＇s syndrome were randomly divided into two groups with equal number.The control group was treated with simple ursodeoxycholic acid treatment,observation group underwent ursodeoxycholic acid and prednisolone therapy.Comparing incidence rate of clinical symptoms：thirst,fatigue,dry eye and itchy; testing liver function indexes ALT,AST,ALP,TBi L,DBil of patients,as well as levels of ALB,Ig G,Ig M and Ig A.Results：Before treatment,clinical symptom incidence rate of both groups,liver function indexes comparing with Ig indexes,differences showed no statistical significance（P〉0.05）; three months after treatment,biochemical indices of treatment group was lower than the control group,liver function indexes were lower than control group,ALB was higher than control group,Ig G,Ig M and Ig A were lower than control group,difference was statistically significant（P〈0.05）.Conclusion：ursodeoxycholic acid combined with prednisolone treating primary biliary cirrhosis with sjogren syndrome was better than single ursodeoxycholic acid treatment,and it could promote liver function and Ig indexes.
出处
《贵州医科大学学报》
CAS
2017年第2期226-229,共4页
Journal of Guizhou Medical University
基金
无锡市医院管理中心科研项目(YGZXY1539)
