摘要
应用硅胶柱色谱、Sephadex LH-20柱色谱及高效制备薄层色谱等方法对念珠根黄芩中的黄酮类化合物进行分离纯化,根据理化性质和波谱数据对其化学结构进行阐明,发现并鉴定了19个黄酮单体,分别为芹菜素(1),木犀草素(2),汉黄芩素(3),千层纸素A(4),6-甲氧基柚皮素(5),5,7,4'-三羟基-6,8-二甲氧基黄酮(6),5,7,8-三甲氧基黄酮(7),3,5,6,7-四甲氧基黄酮(8),7-羟基-4',5,6,8-四甲氧基黄酮(9),5,7,2'-三羟基-6-甲氧基二氢黄酮(10),5,7,4'-三羟基-6-甲氧基黄酮(11),5,7-二羟基-6,8-二甲氧基黄酮(12),5,2',6'-三羟基-7,8-二甲氧基黄酮(13),5,7,2'-三羟基-8-甲氧基黄酮(14),5,2'-二羟基-7,8-二甲氧基二氢黄酮(15),2'-羟基-5,7,8-三甲氧基黄酮(16),5-羟基-7,8-二甲氧基黄酮(17),5,2'-二羟基-7,8-二甲氧基黄酮(18),5-羟基-6,7,8-三甲氧基黄酮(19)。化合物1~19均为首次从念珠根黄芩中发现,化合物6,8,9,12,19为首次从黄芩属植物中发现。
By means of preparative HPTLC and column chromatography over silica gel and Sephadex LH-20,nineteen flavonoids were isolated and purified from the whole plants of Scutellaria moniliorrhiza. Based on the physico-chemical properties and spectral data,their structures were identified as： apigenin（1）,luteolin（2）,wogonin（3）,oroxylin A（4）,6-methoxynaringein（5）,5,7,4＇-trihydroxy-6,8-dimethoxyflavone（6）,5,7,8-trimethoxyflavone（7）,3,5,6,7-tetramethoxyflavone（8）,7-hydroxy-4＇,5,6,8-tetramethoxyflavone（9）,5,7,2＇-trihydroxy-6-methoxyflavanone（10）,5,7,4＇-trihydroxy-6-methoxyflavone（11）,5,7-dihydroxy-6,8-dimethoxy-flavone（12）,5,2＇,6＇-trihydroxy-7,8-dimethoxyflavone（13）,5,7,2＇-trihydroxy-8-methoxyflavone（14）,5,2＇-dihydroxy-7,8-dimethoxyflavanone（15）,2＇-hydroxy-5,7,8-trimethoxyflavone（16）,5-hydroxy-7,8-dimethoxyflavone（17）,5,2＇-dihydroxy-7,8-dimethoxyflavone（18）,and 5-hydroxy-6,7,8-trimethoxyflavone（19）. For the first time,compounds 1-19 were isolated from S. moniliorrhiza,and compounds 6,8,9,12,19 were isolated from the Scutellaria genus.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2017年第9期1699-1703,共5页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(21372189)
关键词
唇形科
黄芩属
念珠根黄芩
黄酮
Lamiaceae
Scutellaria
Scutellaria moniliorrhiza
flavonoids
