摘要
目的探讨拉米夫定治疗乙型肝炎病毒相关性肾炎的临床疗效。方法选择2014年1月~2016年6月在我院诊断治疗的乙型肝炎病毒相关性肾炎患者22例为研究对象。所有患者口服拉米夫定。比较治疗前后24h蛋白尿、血清白蛋白、ALT、HBV-DNA定量水平及Hbe Ag阳性率。分析治疗总有效率。结果 22例患者中9例显效,10例有效,总有效率86.4%。治疗后HBe Ag阳性率显著下降,HBV-DNA及ALT水平较治疗前显著下降,差异有统计学意义(P<0.05)。治疗后患者血清总蛋白水平显著升高,24h尿蛋白定量显著下降,与治疗前比较,差异有统计学意义(P<0.05)。结论拉米夫定治疗乙型肝炎病毒相关性肾炎能够显著改善肾炎症状,降低乙型肝炎相关指标,具有较好的临床疗效。
Objective To discuss the clinical effect of lamivudine in treatment of hepatitis B virus associated gLomerulonephritis. Methods 22 cases with hepatitis B virus associated glomerulonephritis in our hospital from Jan 2014 to Jun 2016 were selected. All cases were treated with lamivudine.24h proteinuria, serum albumin, ALT, HBV- DNA and HbeAg positive rate before and after treatment were compared.Total effective rate was analyzed. Results Of 22 cases,9 cases were effective, 10 cases were valid,and the total effective rate was 86.4%.After treatment,HBeAg pos-itive rate observably decreased,HBV-DNA and ALT were lower than before treatment （P 〈0.05）.After treatment,serum total protein observably increased, and 24h proteinuria was lower than before treatment （P〈0.05）. Conclusion Lamivudine can significantly improve the symptoms of nephritis, reduce the related indicators of hepatitis B. It has good clini-cal efficacy for patients with hepatitis B vims associated gLomerulonephritis.
作者
黄欢
Huang Euan(Guangning County Peopled Hospital, Guangning 52630)
出处
《中国现代医药杂志》
2017年第5期41-43,共3页
Modern Medicine Journal of China
关键词
拉米夫定
乙型肝炎病毒
肾炎
Lamivudine Hepatitis B virus Glomerulonephritis
