摘要
目的:选取穴位贴敷治疗哮喘患者,观察其诱发的急性接触性皮炎严重程度与TSLP、Th2细胞的相关性。方法:选取169例哮喘缓解期患者,在三伏天采用穴位贴敷治疗,依据贴敷后皮肤反应程度分为轻度组及中重度组,观察两组皮炎炎症严重程度与胸腺基质淋巴细胞生成素(TSLP)、Th2细胞表达数量及分布部位的相关性。结果:轻度组单核、淋巴细胞及少量嗜酸性粒细胞(EOS)分布于真皮血管周围;中重度组真皮血管周围分布大量单核、淋巴细胞、EOS。轻度组TSLP少量分布于角质层和真皮层血管周围,少量Th2细胞分布于真皮血管周围;中重度组大量TSLP和Th2细胞分布于角质层和真皮层血管周围。结论:穴位贴敷治疗哮喘诱发急性接触性皮炎局部TSLP与Th2细胞分布部位相同,表达数量与皮炎严重程度呈正向关系。
Objective：To study the relationship between the severity of acute contact dermatitis and TSLP and Th2 cells in asthma patients receiving point application. Methods： 169 patients with remission of asthma were selected and treated with point application on dog day. According to the degree of skin reaction after application, the patients were divided into mild group and moderate-severe group. To observe the relationship between the severity of inflammation and the expression of thymic stromal lymphopoietin （TSLP） and Th2 cells in the two groups. Results ： The mononuclear （：ells, lymphocytes and eosinophils （EOS） in the mild group were distributed around the dermal vessels. There were a large number of mononuclear cells, lymphoeytes and EOS in the moderate-severe group. In the mild group, a small amount of TSLP was distributed in the perivaseular layer of the cuticle and dermis, and a small amount of Th2 cells distributed around the dermal vessels. In the moderate-severe group, a large number of TSLP and Th2 cells distributed in the stratum corneum and dermis perivascular. Conclusion ： The distribution of TSLP and Th2 cells in the treatment of asthma induced acute contact dermatitis by acupoint application was the same as that of the cells, and the expression amount was positively related to the severity of dermatitis.
出处
《辽宁中医药大学学报》
CAS
2017年第5期136-138,共3页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家自然科学基金项目(81674065)
江苏省人力资源与社会保障厅项目(WSN-015)
"十二五"国家科技支撑项目(2015BAIO4B11)
