摘要
目的探讨血清胸腺基质淋巴细胞生成素(TSLP)、血清淀粉样蛋白A(SAA)、C反应蛋白(CRP)在慢性阻塞性肺疾病(COPD)患者不同时期中的水平变化。方法收集慢性阻塞性肺疾病急性加重(AECOPD)患者共33例,以其经治疗后进入稳定期时作为前后对照,健康人16例为正常对照。测定两组血清TSLP、SAA、CRP水平,并分析各指标在COPD不同时期中的变化。结果 COPD组急性期CRP与SAA水平均高于稳定期,TSLP水平低于健康对照组,差异有统计学意义(P<0.05)。COPD患者中CRP与SAA呈正相关(r=0.546,P=0.000)。CRP(AUC=0.797)和SAA(AUC=0.815)在确定COPD患者不同分期中有统计学意义(P<0.05)。结论血清TSLP水平在AECOPD患者下降,CRP和SAA在AECOPD患者增加,其中SAA区分COPD与AECOPD患者的准确性更好。
Objective To value different stages of chronic obstructive pulmonary disease （COPD） patients with the detection of the levels of serum thymie stromal lymphopoietin （TSLP） , serum amyloid A （SAA）, and C-reactive protein （CRP）. Methods A total of 33 patients with COPD during and after hos- pitalization and 16 healthy controls were enrolled in the study from the 3rd affiliated hospital of SYSU. Differences and correlations of the level of serum TSLP, SAA and CRP were analyzed to value the veracity of those factors in different stages of COPD. Results The levels of CRP and SAA were higher in acute exacer- bation of COPD （AECOPD） group than stable COPD group, TSLP was lower in the AECOPD group than the healthy control group （ P 〈 0. 05 ）. CRP had a positive correlation with SAA （ correlation r = 0. 546, P =0. 000） , CRP [area under curve （AUC） =0. 797] and SAA （AUC =0. 815） , and they were statisti- cally significant in identity of different stages of COPD （ P 〈 0. 05 ）. Conclusions Serum TSLP level is de- creased in acute exacerbation phase of COPD, CRP and SAA are increased in AECOPD. SAA is more con- fident in identity of different phases of COPD,
出处
《中国医师杂志》
CAS
2018年第1期46-49,共4页
Journal of Chinese Physician
基金
国家自然科学基金(81370114)~~
