摘要
目的分析帕金森病(PD)患者血清淀粉样蛋白A(SAA)与患者认知功能障碍的关系。方法选取2015年6月-2017年3月第三军医大学第二附属医院神经内科确诊的帕金森病患者110例(PD组)作为研究对象,同期健康体检者60例作为健康对照组。PD组根据H-Y分期分为早期亚组32例,中期亚组47例,晚期亚组31例。检测2组研究对象的血清SAA水平,并采用蒙特利尔认知评估量表(Mo CA)、简易智力状态量表(MMSE)测量PD组患者的认知功能,分析SAA与PD组患者认知功能障碍的关系。结果 PD组患者的血清SAA水平高于健康对照组(t=14.583,P<0.01);Mo CA评分、MMSE评分低于健康对照组(t=11.898、11.572,P<0.05);早期亚组、中期亚组及晚期亚组PD患者的血清SAA水平、Mo CA评分、MMSE评分比较差异具有统计学意义(F=61.094、38.297、40.026,P<0.01)。早期亚组、中期亚组PD亚组患者的Mo CA评分、MMSE评分高于晚期亚组(t=9.084、12.085、11.628、14.482,P<0.05);PD组患者的血清SAA水平与Mo CA评分、MMSE评分均呈负相关关系(r=-0.701、-0.752,P=0.018、0.012)。结论帕金森病患者血清SAA水平升高显著,并且与患者的病情进展、认知功能障碍具有一定的关系。
Objective To investigate the relationship between serum amyloid A （SAA） and cognitive impairment in patients with Parkinsonfi disease （PD）. Methods 110 PD patients （PD group） diagnosed in department of neurology, Sec- ond Affiliated Hospital of Third Military Medical University from June 2015 to March 2017 were selected as the research ob- ject. The same period, 60 healthy subjects enrolled as a control group. The level of serum SAA in two groups of subjects was measured. The cognitive function of.patients in PD group and the cognitive dysfunction in patients with PD were analyzed by Montreal Cognitive Assessment Scale （MoCA） and Simple Mental State Scale （MMSE）. Results Serum SAA levels in pa- tients with PD were higher than those in controls （t = 14. 583, P 〈0.01 ）; MoCA scores and MMSE scores were lower than those in controls （ t = 11. 898, t = 11. 572, P 〈 0.01 ） ; Serum SAA level, MoCA score and MMSE score in early, middle and late subgroups of PD patients were significantly different （ F = 61. 094, F = 38. 297, F = 40.026, P 〈 0.05 ） ; Serum SAA levels in 3 subgroups tended to increase gradually and the differences between groups were statistically significant （t = 13.209, t = 11. 176, P 〈 0.05 ） ; The MoCA score and MMSE score of patients in early subgroup and mid subgroup of PD subgroup were higher than those in advanced subgroup （t = 9.084, t = 12. 085, t = 11. 628, t = 14. 482, P 〈 0. 05）. Serum SAA levels in patients with PD were negatively correlated with MoCA scores and MMSE scores （ r = -0.701, r = -0. 752, P 〈 0.05）. Conclusion Serum SAA levels in patients with Parkinson＇s disease increased significantly, and has a certain rela- tionship with the patient＇s condition and cognitive dysfunction.
出处
《疑难病杂志》
CAS
2018年第2期121-124,共4页
Chinese Journal of Difficult and Complicated Cases
