摘要
目的丁苯酞联合美多芭治疗老年帕金森病效果及其相关指标的变化。方法选择2015年9月—2017年9月辽宁省抚顺市中心医院神经内科诊治帕金森病老年患者86例作为研究对象,随机分成2组,每组43例。对照组以美多芭(多巴丝肼)治疗,观察组则在对照组基础上加用丁苯酞治疗。治疗后8周后对2组患者的临床治疗效果及认知功能、日常生活能力评分(UPDRS评分、MoCA评分、MMSE评分及ADL评分)、1 H-MRS指标(NAA/Cr与Cho/Cr)、氧化应激指标(SOD、NT-3、CRP、MDA)的变化情况进行比较、分析。结果观察组总有效率为93.0%,高于对照组的76. 7%(χ~2=4.441,P=0. 035);2组的UPDRS评分、MoCA评分、MMSE评分及ADL评分均较治疗前明显改善,且观察组改善的更为明显(t=11.344、3.955、3.049、6. 865,均=0. 000);2组的NAA/Cr与Cho/Cr水平均较治疗前明显上升,且观察组上升的更为明显(t=3.674/0. 000、2. 346/0. 011);2组的SOD、NT-3水平均较治疗前明显上升,CRP、MDA水平均较治疗前明显下降,且观察组改善较对照组更为明显(t=26. 803、7. 207、7. 089、7. 663,P均=0.000)。结论丁苯酞联合美多芭治疗老年帕金森病能够获得良好效果,显著改善患者的认知功能、日常生活能力,降低氧化应激指标,效果临床应用。
Objective To observe the effect of butylphthalide combined with levodopa/benserazide in the treatment of senile Parkinson's disease and the changes of related indicators. Methods From September 2015 to September 2017, 86 elderly patients with Parkinson's disease were randomly divided into two groups, 43 in each group. The control group was treated with levodopa/benserazide, while the observation group was treated with butylphthalide on the basis of the control group. Eight weeks after treatment, the clinical efficacy and cognitive function, daily living ability score (UPDRS score, MoCA score, MMSE score and ADL score), 1H-MRS index (NAA/Cr and Cho/Cr), oxidative stress index (SOD, NT-3, CRP, MDA) were compared and analyzed. Results The total effective rate of the observation group was 93.0%, higher than 76.7% of the control group (χ^2=4.441, P =0.035); UPDRS score, MoCA score, MMSE score and ADL score of the two groups were significantly improved compared with before treatment, and the improvement of the observation group was more obvious ( t =11.344, t =3.955, t =3.049, t =6.865, P =0.000); NAA/Cr ho/level of the two groups were significantly higher than before treatment, and the observation group increased more significantly. For obvious ( t/P =3.674/0.000, t/P =2.346/ 0.011 ); SOD and NT-3 levels in the two groups were significantly higher than before treatment, CRP and MDA levels were significantly lower than before treatment, and the improvement in the observation group was more obvious than that in the control group ( t =26.803, t =7.207, t =7.089, t =7.663, P =0.000). Conclusion Butylphthalide combined with levodopa/benserazide in the treatment of senile Parkinson's disease can achieve good results, significantly improve cognitive function, daily living ability, reduce oxidative stress indicators, which is worthy of clinical application.
作者
王大勇
张强
徐斌
杨艳
WANG Dayong;ZHANG Qiang;XU Bin;YANG Yan(Department of Neurology, Fushun Central Hospital,Liaoning Province,Shenyang 113000,China)
出处
《疑难病杂志》
CAS
2019年第1期44-47,共4页
Chinese Journal of Difficult and Complicated Cases
关键词
帕金森病
丁苯酞
美多芭
氧化应激指标
老年人
Parkinson's disease
Butylphthalide
Levodopa/benserazide
Oxidative stress index
Senile
