摘要
目的探讨不同透析方式对慢性肾功能衰竭(chronic renal failure,CRF)患者血清叶酸和维生素B_(12)水平的影响。方法选择2014年1月—2015年3月西安高新医院收治的符合纳入及排除标准的CRF 90例,根据治疗方式不同分为持续性血液透析组、腹膜透析组和未透析组3组各30例,另选择该院同期健康体检者30例作为健康对照组。比较4组血清叶酸和维生素B_(12)水平及采用不同方式治疗CRF 3组低血清叶酸和维生素B_(12)发生率。结果采用不同方式治疗CRF 3组与健康对照组血清叶酸和维生素B_(12)水平总体比较差异均有统计学意义(P<0.05)。血清叶酸和维生素B_(12)水平持续性血液透析组及腹膜透析组均低于健康对照组和未透析组,差异有统计学意义(P<0.05);持续性血液透析组高于腹膜透析组,差异有统计学意义(P<0.05)。采用不同方式治疗CRF 3组低血清叶酸和维生素B_(12)发生率总体比较差异均有统计学意义(P<0.05)。低血清叶酸和维生素B_(12)发生率持续性血液透析组与腹膜透析组均高于未透析组,差异有统计学意义(P<0.05)。结论持续性血液透析及腹膜透析均可使CRF患者血清叶酸和维生素B_(12)水平下降,但持续性血液透析优于腹膜透析,持续性血液透析较腹膜透析更适合CRF患者。
Objective To investigate effects of different hemodialysis ways on serum folic acid and vitamin B12 levels of patients with chronic renal failure （CRF）. Methods A total of 90 CRF patients admitted during January 2014 and March 2015, who were met entering and precluding standard, were selected and divided into continuous hemodialysis group （ n = 30） , peritoneal dialysis group （n =30） and non dialysis group （n =30） , and other 30 healthy people taking medical examination at the same period were selected as control group. Levels of serum folic acid and vitamin B12 levels were compared in four groups, and incidence rates of low serum folic acid and vitamin B12 in the three treatment groups were compared. Results There were significant differences in serum folie acid and vitamin BI2 levels between control group and treatment CRF 3 groups （ P 〈 O. 05 ）. Serum folie acid and vitamin B12 levels in continuous hemodialysis and peritoneal dialysis groups were significantly lower than those in control group and non dialysis group （ P 〈 0.05 ） ; the levels in continuous hemodialysis group were significantly higher than those in peritoneal dialysis group （ P 〈 0.05 ）. The differences in incidence rates of low serum folie acid and low vitamin B12 among treatment CRF 3 groups were statistically significant （P 〈 0. 05 ） ; the incidence rates in continuous hemodialysis and peritoneal dialysis groups were significantly higher than those in non dialysis group （P 〈 0.05）. Conclusion Both Continuous henmtodialysis and peritoneal dialysis can decrease levels of serum folie acid and vitamin B12 of CRF patients, and continuous hematodialysis is better than peritoneal dialysis, and it is more suitable for CRF patients than peritoneal dialysis.
出处
《临床误诊误治》
2017年第5期75-78,共4页
Clinical Misdiagnosis & Mistherapy
基金
陕西省科技厅社发攻关资助项目(2012SF2-22)
关键词
肾功能衰竭
慢性
肾透析
腹膜透析
叶酸
维生素B12
Kidney failure, chronic
Renal dialysis
Peritoneal dialysis
Folic acid
Vitamin B12
