摘要
c-Myc是由原癌基因c-myc编码的、具有bHLH/LZ结构域的转录调节因子,它不仅可以直接或通过其他蛋白质间接调控转录激活,而且能够抑制某些基因的表达。近年来的研究表明,c-Myc通过泛素–蛋白酶体通路维持其在体内的相对稳定,参与调控了细胞增殖、凋亡、细胞周期和细胞代谢等多种生物学功能,其功能异常与多种疾病的发生、发展密切相关。该文综述了泛素–蛋白酶体通路介导细胞内c-Myc蛋白质调控的最新研究进展。
c-Myc, encoded by c-myc protooncogene, is a transcriptional regulatory factor containing bHLH/ LZ domain. It can not only directly or indirectly regulate transcriptional activation, but also inhibit the expression of certain genes. Recent studies showed that c-Myc maintains its stability by the ubiquitin-proteasome pathway and participates in regulating many biological functions, such as cell proliferation, apoptosis, cell cycle and metabolism. Dysregulation of c-Myc is involved in the process of disease development. In this review, we focused on recent advances in the regulation of c-Myc mediated by the ubiquitin-proreasome pathway.
出处
《中国细胞生物学学报》
CAS
CSCD
2017年第4期488-495,共8页
Chinese Journal of Cell Biology
基金
国家重点基础研究发展计划(973计划)(批准号:2013CB932702)
国家自然科学基金(批准号:81272220
81402304
81672760)
湖南省自然科学基金(批准号:2016JJ3048)资助的课题~~
