摘要
蛋白酶体作为蛋白酶家族中一个复杂成员,在真核细胞、古细菌和一些真细菌中均有发现。真核细胞蛋白酶体在蛋白质质量控制和细胞稳态维持中起关键作用,同时涉及多种细胞活动,包括细胞周期运行和抗原提呈等。对真核细胞蛋白酶体在疾病治疗中的作用机制和相关靶点药物的研发已引起了广泛关注。该文综述了真核细胞蛋白酶体结构与功能相关的研究进展,重点阐述了不同形式20S核心颗粒(20S core partical,20S CP)和不同种类调节颗粒间的相互作用。
As a complex member of the protease family, proteasome is found in eukaryotic cells, also in archaea and in some eubacteria. In the eukaryotic ceils, we now know its activity is central to protein quality control and cell homeostasis sustain, invovled in many cellular functions including cell cycle progression and antigen presentation. The role of the treatment of related diseases and the development of target drugs have attracted more attention gradually. This review attempts to summarize the research progress on structure and fuctions of proteasome in eukaryotes, especially on the specific interactions of 20S core partical with its activators.
出处
《中国细胞生物学学报》
CAS
CSCD
2017年第4期515-522,共8页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:31360061)资助的课题~~
