摘要
目的系统评价益气养阴中药治疗中晚期非小细胞肺癌的疗效及安全性。方法计算机检索中国生物医学文献数据库、中国学术期刊全文数据库、维普知识资源系统、Pubmed、Cochrane图书馆数据库,自建库至2016年1月发表的关于益气养阴中药治疗非小细胞肺癌的临床随机对照研究文献,利用Rev Man5.0软件对同质研究合并进行Meta分析,运用Cochrane Reviewer’s Handbook5.0.1评价标准进行质量评价。结果最终纳入17项研究,1 123例受试者。Meta分析结果表明使用益气养阴中药联合化疗的试验组在近期有效率、生存质量、中医症状改善及抑制白细胞及血小板下降和恶心呕吐等不良反应方面均优于单纯使用化疗的对照组。结论益气养阴中药治疗中晚期非小细胞肺癌具有良好的安全性,疗效确切。
Objective To evaluate systemically the effectiveness and safety of Chinese herbal medicines for supplementing qi and nourishing yin used for middle and advanced non-small cell lung cancer. Methods The literatures about the randomized controlled trails of non-small cell lung cancer from the establishment of database up to Jan. 2016 were searched in CNKI, CBM, VIP, Pub Med databases and the Cochrane library website. Homogeneous study and Meta analysis were made by Rev Man5. 0,the quality assessment on the included studies were conducted according to the criteria of Cochrane Reviewer＇s Handbook5. 0. 1. Results A total of 17 studies were included with 1 123 subjects involved. Meta-analysis showed the experiment group with combination of Chinese herbal medicines for supplementing qi and nourishing yin and chemotherapy was superior to the control group with chemotherapy alone in recent effective rate,quality of life,the improvement of TCM symptoms,and the inhibition of white blood cells and platelets decreasing,as well as some side effects,such as nausea and vomiting. Conclusion Chinese herbal medicines for supplementing qi and nourishing yin are safe for the treatment of middle and advanced non-small cell lung cancer with certainty of efficacy.
出处
《北京中医药》
2017年第3期225-231,241,共8页
Beijing Journal of Traditional Chinese Medicine
关键词
益气养阴法
非小细胞肺癌
中医药疗法
系统评价
supplementing Qi and nourishing Yin method
NSCLC
TCM therapy
systematic review
