摘要
目的探讨不同剂量川芎嗪辅助治疗短暂性脑缺血发作患者的疗效及对血清C反应蛋白(CRP)、同型半胱氨酸(Hcy)、脂蛋白联脂酶A2(Lp-PLA2)、神经烯醇化酶(NSE)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平的影响。方法将146例短暂性脑缺血发作患者随机分为2组,A组给予常规治疗方案加川芎嗪注射液120 mg静脉滴注,B组给予常规治疗方案加川芎嗪注射液240 mg静脉滴注,均1次/d,连续治疗2周。检测2组治疗前后血清CRP、Hcy、Lp-PLA2、NSE、TNF-α、IL-6水平,统计2组治疗前4周、治疗2周和治疗后4周短暂性脑缺血发作次数及1年内脑卒中发生率与不良反应发生率。结果 B组治疗后CRP、Hcy、Lp-PLA2、NSE、TNF-α、IL-6水平及大脑中动脉微栓子数目与同期A组比较均显著降低(P均<0.05);B组治疗2周内、治疗后4周短暂性脑缺血发作次数与同期A组比较均显著减少(P均<0.05);B组1年内脑卒中发生率显著低于A组(P<0.05);2组均未见明显药物相关性不良反应。结论大剂量川芎嗪辅助治疗短暂性脑缺血具有更好的临床效果,值得临床推广应用。
Objective It is to explore the curative effect of adjuvant therapy with different dose of ligustrazine in patients with transient ischemic attack and on the levels of serum Creactive protein （CRP）,homocysteine（ Hey） , lipoprotein lipase A2 （ Lp-PLA2） , nerve ene alcoholize enzyme （NSE） , tumor necrosis factor-α （TNF-α） , interleukin 6 （ IL-6 ） . Methods 146 patients with transient ischemic attack were randomly divided into 2 groups, A group was given conventional treatment plus ligustrazine injection 120 mg by intravenous drip, B group was given routine therapy plus ligustrazine injection 240 mg by intravenous drip, once per day, and both groups were treated for 4 weeks. The levels of serum CRP, Hey, Lp-PLA2, NSE, TNF-α, IL-6 were detected before and after treatment in both groups, the times of transient ischemic attack at 4 weeks before treatment, in 2 and 4 weeks after treatment, and incidence of stroke and adverse reactions within 1 year was calculated. Results The levels of CRP, Hey, Lp-pla2, NSE, TNF-α, IL-6 and the number of arterial microemboli in the brain were significantly decreased in group B than those in group A （P 〈 0. 05） . The number of transient ischemic episodes in 2 and 4 weeks after treatment was significantly less while incidence of stoke within 1 year was lower in group B than that in group A （P 〈 0. 05）. No obvious side effect related to the medicine was found in both groups. Conclusion Large doses of ligustrazine has better clinical curative effect on transient ischemia, which is worth clinical promotion.
出处
《现代中西医结合杂志》
CAS
2017年第16期1722-1724,1727,共4页
Modern Journal of Integrated Traditional Chinese and Western Medicine
