摘要
目的 研究短暂性脑缺血发作(TIA)患者血浆溶血磷脂酸(LPA)含量变化的特点及阿司匹林对其的影响,探索TIA的发病机制及有效的干预方法。方法 选取经临床和辅助检查确诊的TIA患者12 8例(TIA组) ,测定其血浆中LPA的含量变化,年龄匹配的110例健康体检者作为对照组。同时观察不同剂量的阿司匹林对TIA患者血浆LPA含量的影响。结果 TIA组患者血浆LPA的含量显著高于对照组(P <0 .0 0 1)。每天给予2 0 0mg阿司匹林较75mg或2 5mg阿司匹林可更有效地降低血浆LPA含量,患者脑缺血发作次数明显减少。结论 TIA患者血浆LPA含量明显升高,适宜剂量的阿司匹林可有效降低血浆LPA的含量,减少脑缺血症状的发作频率。
Objective To investigate the changes of plasma lysophosphatidic acid（LPA） levels in patients with transient ischemic attack（TIA） and to observe whether treatment with aspirin decreases the LPA levels of patients with TIA. Methods Plasma LPA levels were examined using fresh blood in 128 cases of TIA and controls enrolled in the LPA and Stroke Prevention Study. LPA was assayed by measuring its inorganic phosphorus after separation by chromatography. The effects of aspirin at different dosages on plasma LPA levels were observed. Results An elevated LPA level was seen in cases （n = 128） with TIA as compared with 110 controls（P 〈 0.001）. Administration of aspirin （200 mg/d） for one month significantly lowered LPA level （1.66 ±0.21 ） μmol/L of patients（ n = 31） as compared with administration of low-dosage aspirin, and the frequency of TIA. was significantly reduced. Conclusions Plasma LPA levels in patients with TIA was significantly elevated. Aspirin can effectively reduce plasma LPA levels and frequency of TIA.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2005年第2期109-111,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金
国家 973基金资助项目 (G2 0 0 0 0 5 690 5 )
