摘要
目的:探讨血清透明质酸(HA)检测在肝病诊断中的应用。方法:选择2014年1月-2015年12月本院收治的100例肝炎患者作为观察组,所有患者均采用酶联免疫法检测,与无肝胆疾病史的100例健康献血员(对照组)的检测结果对照,并结合病理结果进行分析。结果:观察组患者血清HA水平是随着肝纤维化程度以及肝脏受损程度的不断加重,呈逐渐升高,在G3、G4级和S3、S4期时血清HA水平均呈现出明显升高情况,与对照组比较,差异均有统计学意义(P<0.05)。观察组中肝硬化患者血清HA水平高达(605.3±215.7)μg/L,慢性肝炎患者血清HA达(277.9±126.5)μg/L,与对照组的(91.2±19.6)μg/L比较,差异均有统计学意义(P<0.05)。结论:血清HA水平是诊断肝硬化严重程度以及评估肝纤维化发展趋势的灵敏指标,有较高的临床诊断价值。
Objective： To study the serum hyaluronic acid （ HA ） detection in the diagnosis of liver disease. Method： 100 patients with hepatitis from January 2014 to December 2015 in our hospital were selected as the observation group, all patients were detected by enzyme linked immunosorbent assay （ ELISA ）, the results were compared with those of 100 healthy donors （ control group ） who had no history of hepatobiliary disease, combined with pathological results.Result： The level of serum HA in the observation group was gradually increased with the severity of liver fibrosis and liver damage, the serum HA level in G3, G4 and S3, S4 were significantly higher than those of the control group, the differences were statistically significant （ P〈0.05 ） .The serum HA level of the patients in the observation group was as high as （ 605.3 ± 215.7 ） g/L, and the serum HA of patients with chronic hepatitis was up to （ 277.9 ± 126.5 ） g/L, compared with （ 91.2 ± 19.6 ） g/L in the control group, the differences were statistically significant （ P〈0.05 ） .Conclusion： Serum HA level is a sensitive index for the diagnosis of liver cirrhosis and the development trend of liver fibrosis.
出处
《中国医学创新》
CAS
2017年第12期125-127,共3页
Medical Innovation of China
关键词
血清透明质酸
肝纤维化
肝硬化
检测
炎症
标志物
肝炎
酶联免疫法
Serum hyaluronic acid
Liver fibrosis
Cirrhosis of the liver
Detection
Inflammation
Marker
Hepatitis
Enzyme linked immunosorbent assay
