摘要
目的检测2型糖尿病及糖尿病肾病患者血清中抵抗素水平,探讨血清中抵抗素与2型糖尿病及糖尿病肾病的关系。方法采用酶联免疫法检测40例2型糖尿病无并发症患者、30例2型糖尿病肾病患者及30例健康者的空腹血清中抵抗素和胰岛素水平,同时观测空腹血糖、糖化血红蛋白、胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、体质指数。结果2型糖尿病肾病组的血清中抵抗素水平与正常对照组相比及2型糖尿病无并发症血清抵抗素水平与正常对照组相比,差异均有统计学意义(均P<0.01),而2型糖尿病肾病组与2型糖尿病无并发症组相比,血清抵抗素水平差异无统计学意义(P>0.05)。结论血清抵抗素参与了2型糖尿病及糖尿病肾病的发生,血清抵抗素与2型糖尿病及糖尿病肾病的关系密切。
[Objective]To detect plasma resistin level of patients with type 2 diabetes and diabetic nephropathy,and investigate the relationship between plasma resistin level with type 2 diabetes and diabetic nephropathy.[Methods]ELISA was used to examine fasting plasma and fasting insulin in 40 type 2 diabetes patients without complications,30 type 2 diabetic nephropathy patients and 30 healthy people;and the fasting blood glucose （FBG）,glycosylated hemoglobin （GHBAlc）,total cholesterol （TC）,triglyceride（TG）,HDL-C,LDL-C,body mess index （BMI） were observed simultaneously.[Results] The plasma resistin level of type 2 diabetic nephropathy group and no complications group was significantly different from that of normal control group （P〈0.01）,while between the 2 patients groups,serum resistin level was not significantly different.（P〉0.05）.[Conclusion]Serum resistin involves in type 2 diabetes and diabetic nephropathy.Serum resistin relates closely with type 2 diabetes mellitus and diabetic nephropathy.
出处
《职业与健康》
CAS
2010年第5期582-583,共2页
Occupation and Health
关键词
抵抗素
2型糖尿病
糖尿病肾病
Resistin
Type 2 diabetes mellitus
Diabetic nephropathy
