摘要
目的探讨大株红景天联合脑苷肌肽注射液治疗急性缺血性脑卒中的临床疗效。方法纳入该院2015年6月-2016年6月神经内科收治的60例急性缺血性脑卒中患者,采用随机数字表法分为研究组和对照组,每组各30例,两组均给予常规治疗,对照组加以脑苷肌肽注射液治疗,研究组在对照组治疗的基础上加以大株红景天治疗,比较两组治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、临床疗效,治疗前后血清超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)以及过氧化氢酶(CAT)水平。结果治疗后,两组患者NIHSS评分均较治疗前改善,且研究组改善更明显,比较差异有统计学意义(P<0.05);研究组治疗总有效率为73.33%,对照组的总有效率为56.67%,比较差异有统计学意义(P<0.05);治疗后,两组患者SOD、GSH-Px以及CAT水平均较治疗前明显增高,且研究组上升水平更明显,比较差异有统计学意义(P<0.05);两组均未见明显不良反应。结论大株红景天联合脑苷肌肽注射液治疗急性缺血性脑卒中疗效确切,可显著减轻患者脑内氧化应激损伤,不良反应少,值得临床推广。
[Objective]To evaluate the clinical efficacy of sofren combined with cattle encephalon glycoside and ignotin injection in the treatment of acute ischemic stroke.[Methods]Sixty cases of acute ischemic stroke patients admitted to our hospital from June 2015 to June 2016 were included in the department of neurology,by using the method of random number table,all cases were divided into study group and control group with 30 cases in each.All patients were given routine treatment in two groups.Then the control group was treated with cattle encephalon glycoside and ignotin injection,study group was given large plant rhodiola treatment based on the treatment in control group.National Institute of Health Stroke Scale（NIHSS） score,clinical efficacy,serum superoxide dismutase（SOD）,glutathione peroxidase（GSH-Px） and catalase（CAT） levels before and after treatment in the two groups were compared.[Results]After treatment,NIHSS scores in the two groups were better than before treatment,and the improvement of the study group was more obvious,the difference was statistically significant（P〈0.05）;the total effective rate of the study group was 73.33%,which was significantly increased compared with the control group（P〈0.05）;after treatment,SOD,GSHPx and CAT levels in the two groups were significantly higher than before treatment,and the study group increased significantly（P〈0.05）;there were no significant adverse reactions in the two groups.[Conclusion]Sofren joint cattle encephalon glycoside and ignotin injection in the treatment of acute ischemic stroke is effective,and can significantly reduce the oxidative stress in patients with brain injury,with less adverse reactions,so it is worthy of promotion.
出处
《中国医学工程》
2017年第3期16-19,共4页
China Medical Engineering
关键词
脑苷肌肽注射液
大株红景天
急性缺血性脑卒中
临床疗效
cattle encephalon glycoside and ignotin injection
sofren injection
acute ischemic stroke
clinical curative effect
